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POLDIP2 and PDPK1
Data Source:
BioGRID
(two hybrid)
POLDIP2
PDPK1
Description
DNA polymerase delta interacting protein 2
3-phosphoinositide dependent protein kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Mitochondrion
Mitochondrial Matrix
Mitochondrial Nucleoid
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Focal Adhesion
Postsynaptic Density
Membrane
Cytoplasmic Vesicle
Cell Projection
Perikaryon
Molecular Function
DNA Binding
Protein Binding
Protein Serine/threonine Kinase Activity
3-phosphoinositide-dependent Protein Kinase Activity
Insulin Receptor Binding
Protein Binding
ATP Binding
Phospholipase Activator Activity
Protein Kinase Binding
Phospholipase Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
Negative Regulation Of Macroautophagy
Positive Regulation Of Mitotic Cell Cycle
Mitochondrion Morphogenesis
Error-free Translesion Synthesis
Stimulatory C-type Lectin Receptor Signaling Pathway
Type B Pancreatic Cell Development
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Hyperosmotic Response
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phospholipase Activity
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Cell Migration
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Calcium-mediated Signaling
Actin Cytoskeleton Organization
Platelet Activation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
T Cell Costimulation
Activation Of Protein Kinase B Activity
Cellular Response To Insulin Stimulus
Negative Regulation Of Toll-like Receptor Signaling Pathway
Intracellular Signal Transduction
Fc-epsilon Receptor Signaling Pathway
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of Mast Cell Degranulation
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Focal Adhesion Assembly
T Cell Receptor Signaling Pathway
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Cellular Response To Epidermal Growth Factor Stimulus
Extrinsic Apoptotic Signaling Pathway
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Sprouting Angiogenesis
Positive Regulation Of Vascular Endothelial Cell Proliferation
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
GPVI-mediated activation cascade
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Activation of AKT2
Downstream TCR signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated NF-kB activation
Integrin signaling
CD28 dependent PI3K/Akt signaling
G beta:gamma signalling through PI3Kgamma
RSK activation
VEGFR2 mediated vascular permeability
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases activate PKNs
Constitutive Signaling by AKT1 E17K in Cancer
Regulation of TP53 Degradation
Estrogen-stimulated signaling through PRKCZ
Estrogen-stimulated signaling through PRKCZ
Drugs
Celecoxib
Inositol 1,3,4,5-Tetrakisphosphate
7-Hydroxystaurosporine
Bisindolylmaleimide VIII
Staurosporine
Bisindolylmaleimide I
Dexfosfoserine
10,11-dimethoxy-4-methyldibenzo[c,f]-2,7-naphthyridine-3,6-diamine
5-HYDROXY-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-2-ONE
1-{2-OXO-3-[(1R)-1-(1H-PYRROL-2-YL)ETHYL]-2H-INDOL-5-YL}UREA
2-(1H-imidazol-1-yl)-9-methoxy-8-(2-methoxyethoxy)benzo[c][2,7]naphthyridin-4-amine
3-(1H-indol-3-yl)-4-(1-{2-[(2S)-1-methylpyrrolidinyl]ethyl}-1H-indol-3-yl)-1H-pyrrole-2,5-dione
3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE
Fostamatinib
Diseases
GWAS
Blood protein levels (
29875488
)
Osteoprotegerin levels (
25080503
)
Interacting Genes
19 interacting genes:
AGTRAP
ALAS1
APP
ASCC2
CHCHD2
CPE
DNAAF6
FBXO7
HDAC6
MAD2L2
MTUS2
PCNA
PDPK1
POLD2
POLN
PTEN
REV1
SELENBP1
TAB1
60 interacting genes:
AKT1
AKT2
AKT3
AKTIP
APBB3
APP
BLMH
CARD11
CDAN1
CSK
DDIT4
GIT1
HSP90AA1
ILK
IRS1
ITGB3
KATNBL1
LUC7L2
MAPK8
MTOR
PAK1
PEA15
PHAX
PKN1
PKN2
PNO1
POLDIP2
PRKACA
PRKCB
PRKCD
PRKCE
PRKCI
PRKCZ
PRSS23
PRXL2B
PTK2B
PXN
RALGDS
RPS6KA1
RPS6KA3
RPS6KB1
RPS6KB2
SBF1
SGK1
SGK2
SGK3
SLC9A3R2
SMARCB1
SOCS3
SRC
SRPK1
STRAP
TCAP
WDCP
XPO7
XRCC6
YWHAH
YWHAQ
ZC3HC1
ZNF133
Entrez ID
26073
5170
HPRD ID
17874
05556
Ensembl ID
ENSG00000004142
ENSG00000140992
Uniprot IDs
B4DEM9
Q9Y2S7
O15530
PDB IDs
6Z9C
1H1W
1OKY
1OKZ
1UU3
1UU7
1UU8
1UU9
1UVR
1W1D
1W1G
1W1H
1Z5M
2BIY
2PE0
2PE1
2PE2
2R7B
2VKI
2XCH
2XCK
3H9O
3HRC
3HRF
3ION
3IOP
3NAX
3NAY
3NUN
3NUS
3NUU
3NUY
3ORX
3ORZ
3OTU
3PWY
3QC4
3QCQ
3QCS
3QCX
3QCY
3QD0
3QD3
3QD4
3RCJ
3RWP
3RWQ
3SC1
4A06
4A07
4AW0
4AW1
4CT1
4CT2
4RQK
4RQV
4RRV
4XX9
5ACK
5HKM
5HNG
5HO7
5HO8
5LVL
5LVM
5LVN
5LVO
5LVP
5MRD
Enriched GO Terms of Interacting Partners
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