CD2BP2 and CD2

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		CD2BP2	CD2
Description		CD2 cytoplasmic tail binding protein 2	CD2 molecule
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm U5 SnRNP Cytoplasm Cytosol Nuclear Speck U4/U6 X U5 Tri-snRNP Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction External Side Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Cell Surface Protein-containing Complex Membrane Raft Anchored Component Of Plasma Membrane
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	Signaling Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Identical Protein Binding Protein Self-association
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly MRNA Splicing, Via Spliceosome Negative Regulation Of Phosphatase Activity	Membrane Raft Polarization Apoptotic Process Cell Surface Receptor Signaling Pathway Natural Killer Cell Activation Positive Regulation Of Myeloid Dendritic Cell Activation Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion T Cell Activation Regulation Of T Cell Differentiation Leukocyte Migration Cell-cell Adhesion
Pathways		mRNA Splicing - Major Pathway	Cell surface interactions at the vascular wall
Drugs			Alefacept Siplizumab
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545)	Body mass index ( 28552196) Gout (normal type) ( 32238385) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676)
Interacting Genes		14 interacting genes: ACAD11 AKNA CD2 CHRM3 CSNK2A1 LRRK1 PRPF6 PSMF1 SMU1 SNRPB TRAPPC6A TXNL4A WBP11 ZNHIT2	21 interacting genes: CD247 CD2AP CD2BP2 CD4 CD48 CD5 CD53 CD58 CD59 DNAJC5 FYN LCK LGALS1 LINC00311 LYAR MXD1 PSTPIP1 PTPRC SH3KBP1 SP1 UBC
Entrez ID		10421	914
HPRD ID		05127	01750
Ensembl ID		ENSG00000169217	ENSG00000116824
Uniprot IDs		A0A024QZC1 O95400	P06729 Q53F96
PDB IDs		1GYF 1L2Z 1SYX 4BWS	1CDB 1GYA 1HNF 1L2Z 1QA9 2J6O 2J7I
Enriched GO Terms of Interacting Partners?
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