ANAPC10 and CDC27

Data Source:
BioGRID (affinity chromatography technology, biochemical, affinity chromatography technology, biochemical)
HPRD (in vitro)

		ANAPC10	CDC27
Description		anaphase promoting complex subunit 10	cell division cycle 27
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GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Centrosome Spindle Cytosol Mitotic Spindle
	Molecular Function		Protein Binding Protein Phosphatase Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Protein K11-linked Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adult body size ( 32376654) Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (MOSTest) ( 32665545) Height ( 25282103 25429064 31562340) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference ( 25673412) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 27863252) Mean corpuscular volume ( 27863252) Mean reticulocyte volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Body mass index ( 26426971) Diffusing capacity of carbon monoxide ( 30694715)
Interacting Genes		16 interacting genes: ANAPC11 ANAPC7 CDC16 CDC20 CDC23 CDC27 FZR1 LIG4 LRP1 LRP2 LRP8 MAPK8IP2 PTEN SMAD2 SMAD3 TSC22D2	29 interacting genes: ADNP ANAPC10 ANAPC2 ANAPC4 ANAPC7 BUB1B CASP3 CCNB1 CDC16 CDC20 CDC26 CKS1B COMT CTNNB1 DCPS FZR1 GKN1 HOXC10 HSF2 MAD2L1 PIN1 PPP5C PTEN PTTG1 RB1 SKIL SMAD2 SMAD3 UBE2S
Entrez ID		10393	996
HPRD ID		16488	00304
Ensembl ID		ENSG00000164162	ENSG00000004897
Uniprot IDs		Q9UM13	B4DL80 G5EA36 P30260
PDB IDs		1JHJ 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5	3T1N 4RG6 4RG7 4RG9 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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