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BTN2A2 and PSMA3
Data Source:
BioGRID
(two hybrid)
BTN2A2
PSMA3
Description
butyrophilin subfamily 2 member A2
proteasome 20S subunit alpha 3
Image
No pdb structure
GO Annotations
Cellular Component
Plasma Membrane
External Side Of Plasma Membrane
Integral Component Of Membrane
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Synapse
Extracellular Exosome
Molecular Function
Signaling Receptor Binding
Protein Binding
Endopeptidase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Regulation Of Cytokine Production
Negative Regulation Of Cytokine Production
Negative Regulation Of Cellular Metabolic Process
Negative Regulation Of Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Regulation Of Endopeptidase Activity
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
Butyrophilin (BTN) family interactions
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
Diseases
GWAS
Autism spectrum disorder or schizophrenia (
28540026
)
Brain morphology (MOSTest) (
32665545
)
Fish- and plant-related diet (
32066663
)
General cognitive ability (
29844566
)
Headache (
29397368
)
Intelligence (MTAG) (
29326435
)
Neurociticism (
29500382
)
Refractive error (
32231278
)
Schizophrenia (
19571809
)
Subcortical volume (MOSTest) (
32665545
)
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Interacting Genes
42 interacting genes:
AQP6
BIK
CD53
CD79A
CISD2
CREB3
EBP
ELOVL4
EMP1
ERGIC3
EVI2B
FAM209A
FATE1
FFAR2
GJB3
GPR42
GPRC5D
GPX8
HSD3B7
KIR2DL3
LHFPL5
LMNA
MRM3
MUC1
PEX12
PSMA3
SEC11C
SLC10A6
SLC14A1
SLC16A2
SLC1A3
SLC30A4
SLC39A2
SPNS3
STX1A
SYT1
TMEM14B
TMEM179B
TMEM237
TMEM31
TMEM52B
TMX2
113 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
C9orf106
CCDC69
CCL28
CDK6
CDKN1A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RBM42
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TRIB3
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
Entrez ID
10385
5684
HPRD ID
12545
01463
Ensembl ID
ENSG00000124508
ENSG00000100567
Uniprot IDs
A0A024R038
Q8WVV5
A0A140VK43
P25788
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
Enriched GO Terms of Interacting Partners
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