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PSMA3 and HSPB1
Data Source:
BioGRID
(two hybrid)
PSMA3
HSPB1
Description
proteasome 20S subunit alpha 3
heat shock protein family B (small) member 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Core Complex
Proteasome Core Complex, Alpha-subunit Complex
Synapse
Extracellular Exosome
Proteasome Complex
Extracellular Space
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Focal Adhesion
Extracellular Exosome
Axon Cytoplasm
Molecular Function
Endopeptidase Activity
Protein Binding
Ubiquitin Protein Ligase Binding
RNA Binding
Protein Kinase C Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Protein Folding Chaperone
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Proteasomal Ubiquitin-independent Protein Catabolic Process
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Regulation Of Endopeptidase Activity
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Retina Homeostasis
Regulation Of Protein Phosphorylation
Regulation Of Translational Initiation
Negative Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Response To Virus
Regulation Of Autophagy
Viral Process
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Chaperone-mediated Protein Folding
Platelet Aggregation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Anterograde Axonal Protein Transport
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
VEGFA-VEGFR2 Pathway
AUF1 (hnRNP D0) binds and destabilizes mRNA
MAPK6/MAPK4 signaling
Extra-nuclear estrogen signaling
Drugs
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE
Phenethyl Isothiocyanate
Apatorsen
Artenimol
Phenethyl Isothiocyanate
Diseases
Distal hereditary motor neuropathies (dHMN)
GWAS
Brain morphology (MOSTest) (
32665545
)
Mean corpuscular hemoglobin (
27863252
)
Mean corpuscular volume (
27863252
)
Red blood cell count (
32888494
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Schizophrenia (
30285260
)
Interacting Genes
113 interacting genes:
ADGRL1
APLN
ATN1
ATP6V0C
AURKB
BTN2A2
BTRC
C1orf105
C9orf106
CCDC69
CCL28
CDK6
CDKN1A
CRB3
CRYAB
CSNK2A1
CST2
CTBP1-DT
CYBA
DDX5
DGLUCY
DMC1
DMRT3
DVL1
EGR1
FAM171A2
FAM218A
FAM83A
FBXL18
FRAT1
GATA2
GATA3
GFI1B
GORASP2
HHEX
HSPB1
IKBKG
IQCE
KIF1A
KIRREL2
KIRREL3-AS3
KRAS
KRTAP19-5
KRTAP26-1
KRTAP8-1
LASP1
LBP
LETM1
LINC00908
MDM2
MIA2
NEU4
NOL4L-DT
NPBWR2
NPPB
NUMBL
OSR2
PATL1
PCOTH
PLK1
PML
POMP
PRELID3A
PRNP
PRR13
PRR3
PRRC2A
PSMA1
PSMA2
PSMA4
PSMA6
PSMA7
PSMB10
PSMB5
PTPN23
PWWP2B
PWWP3A
RAB3IL1
RAD54L2
RAMAC
RBFOX2
RBM42
RERE
RFT1
RTP5
RUSC1-AS1
SERF2
SF1
SH3KBP1
SLAIN1
SLC22A23
SNRPB
SNRPC
SNRPF
SPATA8
SRPK2
STUB1
STX11
STX1A
STX4
STX6
TBC1D16
TBX6
TCF7L2
TINCR
TRIB3
URB1-AS1
VPS37C
XRN2
YPEL3
ZNF366
ZNF385C
ZNF688
254 interacting genes:
ACAP2
ACBD6
ACTC1
ACTN1
ACTN2
ACTN4
ADCY9
ADD3
ADPRS
AGAP10P
AGAP3
AGAP4
AGAP5
AGAP7P
AKT1
ALPI
AMD1
ANAPC7
ANK1
ANKRD7
ANXA1
AP2B1
APPL1
ARHGAP28
ARHGEF7
ARIH1
ARMT1
ARRDC5
ATXN10
BAG3
BICDL1
BVES
C11orf98
C2orf73
CAMK1
CBX1
CCDC32
CCDC70
CCHCR1
CCNC
CCNDBP1
CCNO
CDC123
CDK5RAP3
CENPK
CEP78
CETN3
CFAP251
CLCN3
CPSF3
CRNKL1
CRYAA
CRYAB
CRYBB2
CRYGC
CS
CYCS
DAXX
DES
DMAP1
DNAJC21
ECPAS
EHD1
EIF1AX
EIF2S1
EIF3M
EIF4G1
EIF4G3
EIF5
ENPP2
EPB41L1
EPB41L2
EPB41L3
ERCC5
ERICH6
ESR1
FAM71D
FLNB
FXR1
GAPVD1
GDI2
GLMN
GNPAT
GOLGA8A
GRIPAP1
GRK3
GSTO1
GTSF1
GUCA1A
HAUS8
HDLBP
HECTD1
HNRNPA2B1
HNRNPD
HNRNPF
HNRNPU
HSP90AB1
HSPA4
HSPA5
HSPB8
HUWE1
IARS2
IGBP1
IGSF21
INPP5K
INS
ISG20L2
KANSL1
KCMF1
KCTD3
KLC1
KNSTRN
KPNA3
KRT18
KRT72
LBP
LIG1
LONRF1
LRIF1
LSM3
LUZP1
MAPK14
MAPKAPK2
MAPKAPK3
MAPKAPK5
MAPT
MCM6
MDH2
MED31
MFAP1
MPHOSPH6
MRGBP
MRPL28
MRPL40
MRPS23
MSL1
MTIF2
MYG1
MYL12A
MYL12B
MYL9
MYLK
NAP1L1
NAPA
NBAS
NCKIPSD
NEK10
NEXN
NFKBIA
NFU1
NSMCE4A
NVL
OBSL1
OPTN
OSBPL9
PAF1
PALM3
PELO
PGM2
PHYHIPL
PLG
PNISR
PNPT1
POP7
PPA1
PPM1A
PPP2R3C
PRPF19
PRPF40A
PSMA3
PSMA6
PSMB2
PSMC1
PSMD1
PTGES3
PTPN3
PTPRA
RAB41
RAD23A
RALA
RASSF9
RBM25
RBM39
RBM48
RBPJ
RPAP3
RPSA
RSPH3
RYBP
S100A4
SAT1
SBF1
SEC13
SERTAD1
SF3A3
SF3B3
SLC7A9
SMARCA2
SMARCA4
SMARCD1
SNRNP200
SNRPF
SPACA7
SPATA7
SPIN1
SPTBN1
SQSTM1
SRP72
STUB1
SUMO2
SUPT5H
SYCE1
TARBP2
TARS1
TBC1D1
TBC1D3B
TGFB1I1
TGM1
THOC5
TJP2
TMCO3
TOMM70
TOX4
TP53
TPT1
TRIM24
TRIM54
TRIM55
TRIM63
TSNAXIP1
TTC3
TTC39C
TXNL1
UCHL5
UFD1
UQCC2
UQCRB
VIM
WASHC3
WDR83
WWP1
XPO1
XRCC5
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB17
ZBTB37
ZFAT
ZNF131
ZNF197
ZNRF3
Entrez ID
5684
3315
HPRD ID
01463
09076
Ensembl ID
ENSG00000100567
ENSG00000106211
Uniprot IDs
A0A140VK43
P25788
P04792
V9HW43
PDB IDs
4R3O
4R67
5A0Q
5DSV
5GJQ
5GJR
5L4G
5LE5
5LEX
5LEY
5LEZ
5LF0
5LF1
5LF3
5LF4
5LF6
5LF7
5LN3
5M32
5T0C
5T0G
5T0H
5T0I
5T0J
5VFO
5VFP
5VFQ
5VFR
5VFS
5VFT
5VFU
6AVO
6E5B
6KWY
6MSB
6MSD
6MSE
6MSG
6MSH
6MSJ
6MSK
6R70
6REY
6RGQ
6WJD
6WJN
6XMJ
2N3J
3Q9P
3Q9Q
4MJH
6DV5
6GJH
Enriched GO Terms of Interacting Partners
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