APBB3 and RAB4A

Data Source:
HPRD (two hybrid)

		APBB3	RAB4A
Description		amyloid beta precursor protein binding family B member 3	RAB4A, member RAS oncogene family
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Actin Cytoskeleton Membrane	Endosome Cytosol Plasma Membrane Cytoplasmic Vesicle Membrane Early Endosome Membrane Vesicle Insulin-responsive Compartment Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Membrane Extracellular Exosome Postsynaptic Recycling Endosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Amyloid-beta Binding Protein Binding Transcription Factor Binding Low-density Lipoprotein Particle Receptor Binding	ATPase Activator Activity GTPase Activity Protein Binding GTP Binding GDP Binding Syntaxin Binding Ionotropic Glutamate Receptor Binding ATPase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Secretion	Phosphatidylinositol Biosynthetic Process Protein Transport Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of ATPase Activity
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane TBC/RABGAPs RAB geranylgeranylation MET receptor recycling
Drugs
Diseases
GWAS		Serum immune biomarker levels ( 32066700)	Aging ( 22773346) Leukoderma in response to rhododendrol ( 32558222) Mean arterial pressure (alcohol consumption interaction) ( 24376456) Mercury levels ( 26025379) Response to antidepressants in depression ( 27622933)
Interacting Genes		6 interacting genes: APLP2 APP EGFR ERBB2 PDPK1 RAB4A	33 interacting genes: ACTB APBB3 CD2AP CDK1 CHM DYNC1LI1 DYNLL1 EXOC5 FAM71C GDI2 GRIPAP1 HACE1 IDH3A KCTD7 KIF3B MAPK3 PIN1 PRKCI PTTG1IP RAB11FIP1 RAB7A RABAC1 RABEP1 RABEP2 RABGAP1 RABGEF1 RBSN RUFY1 SOD2 STX4 TP53 VPS52 ZNF830
Entrez ID		10307	5867
HPRD ID		04089	01541
Ensembl ID		ENSG00000113108	ENSG00000168118
Uniprot IDs		O95704 Q59EH2 Q96DX9	A0A024R3U9 A0A087WYT5 P20338
PDB IDs		2DYQ 2YSC	1YU9 1Z0K 2BMD 2BME
Enriched GO Terms of Interacting Partners?
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