BET1 and PTGES

Data Source:
BioGRID (two hybrid)

		BET1	PTGES
Description		Bet1 golgi vesicular membrane trafficking protein	prostaglandin E synthase
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GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Endoplasmic Reticulum Membrane Membrane Transport Vesicle Integral Component Of Golgi Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Nuclear Envelope Lumen Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	SNAP Receptor Activity Protein Binding	Glutathione Transferase Activity Glutathione Peroxidase Activity Prostaglandin-D Synthase Activity Protein Binding Glutathione Binding Prostaglandin-E Synthase Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus	Prostaglandin Biosynthetic Process Acute Inflammatory Response Chronic Inflammatory Response Prostaglandin Metabolic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Response To Organic Cyclic Compound Sensory Perception Of Pain Cyclooxygenase Pathway Regulation Of Fever Generation Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Response To Retinoic Acid Response To Cytokine Regulation Of Inflammatory Response Response To Calcium Ion Cellular Oxidant Detoxification
Pathways		COPII-mediated vesicle transport COPI-mediated anterograde transport	Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs
Diseases
GWAS		Aging ( 22773346) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) BRCA1/2-negative high-risk breast cancer ( 30323354) Obesity-related traits ( 23251661) World class endurance athleticism ( 26824906)	Asthma ( 27611488) Pars orbitalis volume ( 31530798)
Interacting Genes		52 interacting genes: ADORA2A ANKS6 AQP6 ASGR2 ASZ1 BCL2L13 CD74 CD79A CGRRF1 CISD2 CLDN7 CLEC10A CRB3 CREB3L1 CYB561 CYBC1 ELOVL4 ERGIC3 FAM174A FAM209A FAM210B FAM9B GOSR2 GPR152 GPX8 JAGN1 KASH5 KCNJ6 LYPD5 MAGEA6 MFF MGST3 NAPB PTGES REEP4 RETREG3 SLC26A6 SLC7A14 SNTG2 SSMEM1 STX1A STX1B STX2 STX4 STX5 TMCO5A TMEM237 TMEM35A TMEM52B TMEM80 TMX2 USHBP1	18 interacting genes: BET1 C4orf3 EHHADH GIMAP1 GIMAP5 PLP2 PTGER1 PTGER2 SEC22A SERP2 SMCO4 TMEM19 TMEM222 TMEM65 VAMP3 VAMP4 VAPB YIF1A
Entrez ID		10282	9536
HPRD ID		16107	05528
Ensembl ID		ENSG00000105829	ENSG00000148344
Uniprot IDs		O15155 Q53XK0	O14684
PDB IDs		3EGX	3DWW 4AL0 4AL1 4BPM 4WAB 4YK5 4YL0 4YL1 4YL3 5BQG 5BQH 5BQI 5K0I 5T36 5T37 5TL9
Enriched GO Terms of Interacting Partners?
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