AKAP8 and MCM2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		AKAP8	MCM2
Description		A-kinase anchoring protein 8	minichromosome maintenance complex component 2
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Mitochondrion Golgi Apparatus Membrane Nuclear Matrix	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Nucleolus Cytoplasm MCM Complex CMG Complex
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding NF-kappaB Binding	DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded DNA Helicase Activity Enzyme Binding Histone Binding 3'-5' DNA Helicase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Signal Transduction Protein Transport Positive Regulation Of Histone Deacetylation Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Histone Phosphorylation Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation Nucleosome Assembly Apoptotic Process Cellular Response To Interleukin-4 Cochlea Development Mitotic DNA Replication Initiation Negative Regulation Of DNA Helicase Activity
Pathways			Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Red cell distribution width ( 32888494) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 MCM2 PRKAR2A RELA	57 interacting genes: AKAP8 APP ASF1A ATM ATR CCNB2 CCNC CDC45 CDC6 CDC7 CDK2 CDK4 CDK6 CDKN2A CDT1 CPSF1 CSNK2A1 DBF4 ELL EP300 ESCO2 FBXO7 GINS4 GNB5 GTF2B GTF2H1 H3-4 KAT7 MCM10 MCM3 MCM4 MCM5 MCM6 MCM7 MCPH1 MOB4 MPP3 ORC1 ORC2 ORC4 ORC5 ORC6 P2RX4 PHB PHC2 PLK1 PTEN RAD52 RPA1 RPA2 RPA3 RPS4X SIK1 TBP TCEA2 TERF1 TERF2IP
Entrez ID		10270	4171
HPRD ID		05258	00303
Ensembl ID		ENSG00000105127	ENSG00000073111
Uniprot IDs		O43823	P49736
PDB IDs			4UUZ 5BNV 5BNX 5BO0 5C3I 5JA4 6XTX 6XTY 6YA7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?