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MCM2 and PLK1
Data Source:
HPRD
(in vivo)
MCM2
PLK1
Description
minichromosome maintenance complex component 2
polo like kinase 1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Nucleolus
Cytoplasm
MCM Complex
CMG Complex
Kinetochore
Chromatin
Synaptonemal Complex
Spindle Pole
Condensed Nuclear Chromosome Outer Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Centriole
Spindle
Cytosol
Spindle Microtubule
Microtubule Cytoskeleton
Midbody
Centriolar Satellite
Spindle Midzone
Mitotic Spindle Pole
Molecular Function
DNA Binding
DNA Replication Origin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Single-stranded DNA Helicase Activity
Enzyme Binding
Histone Binding
3'-5' DNA Helicase Activity
Metal Ion Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Microtubule Binding
Anaphase-promoting Complex Binding
Kinase Activity
Protein Kinase Binding
Identical Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
Nucleosome Assembly
Apoptotic Process
Cellular Response To Interleukin-4
Cochlea Development
Mitotic DNA Replication Initiation
Negative Regulation Of DNA Helicase Activity
Mitotic Sister Chromatid Segregation
G2/M Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Establishment Of Mitotic Spindle Orientation
Mitotic Cell Cycle
Mitotic Cytokinesis
Microtubule Bundle Formation
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Sister Chromatid Cohesion
Mitotic Nuclear Envelope Disassembly
Mitotic Spindle Assembly Checkpoint
Centrosome Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of G2/M Transition Of Mitotic Cell Cycle
Positive Regulation Of Peptidyl-threonine Phosphorylation
Female Meiosis Chromosome Segregation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Regulation Of Mitotic Metaphase/anaphase Transition
Anaphase-promoting Complex-dependent Catabolic Process
Protein Destabilization
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cytokinesis
Negative Regulation Of Apoptotic Process
Regulation Of Protein Binding
Homologous Chromosome Segregation
Establishment Of Protein Localization
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Proteolysis
Nuclear Envelope Disassembly
Positive Regulation Of Ubiquitin-protein Transferase Activity
Regulation Of Cell Cycle
Synaptonemal Complex Disassembly
Protein Localization To Chromatin
Signal Transduction Involved In G2 DNA Damage Checkpoint
Protein Localization To Nuclear Envelope
Ciliary Basal Body-plasma Membrane Docking
Positive Regulation Of Protein Localization To Nucleus
Regulation Of Mitotic Spindle Assembly
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Cell Cycle G2/M Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Regulation Of Protein Localization To Cell Cortex
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Polo-like kinase mediated events
Golgi Cisternae Pericentriolar Stack Reorganization
Golgi Cisternae Pericentriolar Stack Reorganization
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Phosphorylation of the APC/C
Phosphorylation of Emi1
Condensation of Prophase Chromosomes
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
Regulation of PLK1 Activity at G2/M Transition
Activation of NIMA Kinases NEK9, NEK6, NEK7
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization from the centrosome
Recruitment of NuMA to mitotic centrosomes
Anchoring of the basal body to the plasma membrane
RHO GTPases Activate Formins
Mitotic Prometaphase
Mitotic Metaphase/Anaphase Transition
Mitotic Telophase/Cytokinesis
Cyclin A/B1/B2 associated events during G2/M transition
The role of GTSE1 in G2/M progression after G2 checkpoint
AURKA Activation by TPX2
EML4 and NUDC in mitotic spindle formation
Drugs
3-[3-chloro-5-(5-{[(1S)-1-phenylethyl]amino}isoxazolo[5,4-c]pyridin-3-yl)phenyl]propan-1-ol
3-[3-(3-methyl-6-{[(1S)-1-phenylethyl]amino}-1H-pyrazolo[4,3-c]pyridin-1-yl)phenyl]propanamide
4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE
1-[5-Methyl-2-(trifluoromethyl)furan-3-yl]-3-[5-[2-[[6-(1H-1,2,4-triazol-5-ylamino)pyrimidin-4-yl]amino]ethyl]-1,3-thiazol-2-yl]urea
Wortmannin
Fostamatinib
Diseases
GWAS
Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) (
28090653
)
Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) (
29455858
)
Red cell distribution width (
32888494
)
Refractive error (
32231278
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Interacting Genes
57 interacting genes:
AKAP8
APP
ASF1A
ATM
ATR
CCNB2
CCNC
CDC45
CDC6
CDC7
CDK2
CDK4
CDK6
CDKN2A
CDT1
CPSF1
CSNK2A1
DBF4
ELL
EP300
ESCO2
FBXO7
GINS4
GNB5
GTF2B
GTF2H1
H3-4
KAT7
MCM10
MCM3
MCM4
MCM5
MCM6
MCM7
MCPH1
MOB4
MPP3
ORC1
ORC2
ORC4
ORC5
ORC6
P2RX4
PHB
PHC2
PLK1
PTEN
RAD52
RPA1
RPA2
RPA3
RPS4X
SIK1
TBP
TCEA2
TERF1
TERF2IP
120 interacting genes:
-
ACTL6B
APP
ASPM
BAG6
BCL2L1
BIRC6
BRCA2
BUB1
BUB1B
C6orf136
CCDC115
CCNB1
CDC14A
CDC25C
CENPQ
CEP55
CHEK2
CSN1S1
CSN2
CTNNB1
DNAJB9
DNHD1
ECT2
EIF6
FBXL5
FBXW7
FZR1
GET4
GLB1
GORASP1
IKBKB
INTS11
ITSN1
KIF23
KIF2C
KLF4
KLHL22
KRBA1
LMO4
LRP5L
LRRK1
LRRK2
MAD2L1BP
MAGED1
MCM2
MCM3
MCM7
MDM2
MPP2
MYC
MYT1
NEDD4
NHSL2
NINL
NPM1
NUDC
PARP10
PHC2
PIN1
PITPNM1
PKMYT1
PLK3
PPID
PRC1
PRKN
PSMA1
PSMA3
PSMA4
PSMA5
PSMA6
PSMA7
PSMB1
PSMB2
PSMB3
PSMB4
PSMB5
PSMB6
PSMB7
PTEN
PTPRD
RABAC1
RACGAP1
RAD51
RAP1GAP
RECQL5
RELA
REST
RGCC
RICTOR
RNF126
RNF2
RXRA
SIMC1
SNCA
SNCB
SPOUT1
SREBF1
STAG2
STK3
STUB1
SUGT1
TANK
TNFSF11
TOP2A
TP53
TP53BP2
TP73
TPT1
TRIOBP
TSC1
TUBA4A
TUBB
TUBB3
TUBG1
USP16
USP7
VRK3
WEE1
ZNF71
Entrez ID
4171
5347
HPRD ID
00303
03652
Ensembl ID
ENSG00000073111
ENSG00000166851
Uniprot IDs
P49736
P53350
PDB IDs
4UUZ
5BNV
5BNX
5BO0
5C3I
5JA4
6XTX
6XTY
6YA7
1Q4K
1Q4O
1UMW
2OGQ
2OJX
2OU7
2OWB
2RKU
2V5Q
2YAC
3BZI
3C5L
3FC2
3FVH
3HIH
3HIK
3KB7
3P2W
3P2Z
3P34
3P35
3P36
3P37
3Q1I
3RQ7
3THB
4A4L
4A4O
4DFW
4E67
4E9C
4E9D
4H5X
4H71
4HAB
4HCO
4HY2
4J52
4J53
4LKL
4LKM
4O56
4O6W
4O9W
4RCP
4WHH
4WHK
4WHL
4X9R
4X9V
4X9W
5J19
5NEI
5NFU
5NJE
5NMM
5NN1
5NN2
5TA6
5TA8
6AX4
6GY2
Enriched GO Terms of Interacting Partners
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