AKAP8 and DDX5

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		AKAP8	DDX5
Description		A-kinase anchoring protein 8	DEAD-box helicase 5
Image		No pdb structure
GO Annotations	Cellular Component	Condensed Chromosome Female Pronucleus Nucleus Nucleoplasm Nucleolus Mitochondrion Golgi Apparatus Membrane Nuclear Matrix	Nucleus Nucleoplasm Nucleolus Cytoplasm Membrane Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Zinc Ion Binding Protein Kinase A Regulatory Subunit Binding Histone Deacetylase Binding NF-kappaB Binding	RNA Binding RNA Helicase Activity MRNA 3'-UTR Binding Protein Binding ATP Binding MH2 Domain Binding Pre-mRNA Binding Ribonucleoprotein Complex Binding SMAD Binding Androgen Receptor Binding R-SMAD Binding Primary MiRNA Binding Promoter-specific Chromatin Binding
	Biological Process	Mitotic Cell Cycle Mitotic Chromosome Condensation Signal Transduction Protein Transport Positive Regulation Of Histone Deacetylation Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Histone Phosphorylation Cell Cycle G2/M Phase Transition Innate Immune Response Cellular Response To Lipopolysaccharide Cellular Response To Prostaglandin E Stimulus	Negative Regulation Of Transcription By RNA Polymerase II Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome Nuclear-transcribed MRNA Catabolic Process Epithelial To Mesenchymal Transition Regulation Of Transcription By RNA Polymerase II MRNA Transcription BMP Signaling Pathway Intracellular Estrogen Receptor Signaling Pathway Androgen Receptor Signaling Pathway Positive Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Myoblast Differentiation Regulation Of Osteoblast Differentiation Rhythmic Process Regulation Of Androgen Receptor Signaling Pathway Pri-miRNA Transcription By RNA Polymerase II Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Regulation Of Skeletal Muscle Cell Differentiation
Pathways			SUMOylation of transcription cofactors mRNA Splicing - Major Pathway Estrogen-dependent gene expression Replication of the SARS-CoV-1 genome Replication of the SARS-CoV-2 genome
Drugs			Artenimol
Diseases			Prostate cancer
GWAS			Lung function (FVC) ( 30804560) Refractive error ( 32231278)
Interacting Genes		10 interacting genes: AMY1A CASP3 CCND1 CCND2 CCND3 CSNK2A1 DDX5 MCM2 PRKAR2A RELA	37 interacting genes: AKAP8 CALM1 CREBBP DDX17 DHX9 DUX4 EP300 ESR1 FBL FRS3 HNRNPA0 HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK IL7R KHDRBS1 MAPKAPK2 NCOA1 NCOA2 NCOA3 NDRG1 PIAS1 PIK3CA PIN1 PRKCA PSMA3 RBFOX2 RBM10 RBM4 SMAD3 SP1 SUMO2 TNNT1 TP53 UBE2I WBP11
Entrez ID		10270	1655
HPRD ID		05258	01615
Ensembl ID		ENSG00000105127	ENSG00000108654
Uniprot IDs		O43823	J3KTA4 P17844
PDB IDs			3FE2 4A4D
Enriched GO Terms of Interacting Partners?
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