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CDKN1B and YWHAH
Data Source:
HPRD
(in vitro, in vivo)
CDKN1B
YWHAH
Description
cyclin dependent kinase inhibitor 1B
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Endosome
Cytosol
Cul4A-RING E3 Ubiquitin Ligase Complex
Intracellular Membrane-bounded Organelle
Cytoplasm
Mitochondrion
Cytosol
Plasma Membrane
Intercalated Disc
Extracellular Exosome
Molecular Function
Protein Kinase Inhibitor Activity
Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity
Protein Binding
Protein Kinase Binding
Protein Phosphatase Binding
Cyclin Binding
Protein-containing Complex Binding
Chaperone Binding
Actin Binding
Insulin-like Growth Factor Receptor Binding
Protein Binding
Sodium Channel Regulator Activity
Enzyme Binding
Protein Domain Specific Binding
Glucocorticoid Receptor Binding
Identical Protein Binding
Ion Channel Binding
Protein Heterodimerization Activity
Biological Process
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G1/S Transition Of Mitotic Cell Cycle
DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest
Cell Cycle Arrest
Heart Development
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Cell Death
Negative Regulation Of Cell Growth
Negative Regulation Of Kinase Activity
Negative Regulation Of Phosphorylation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Negative Regulation Of Cell Cycle
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Mitotic Cell Cycle
Autophagic Cell Death
Cellular Response To Lithium Ion
Mitotic Cell Cycle Arrest
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Negative Regulation Of Cardiac Muscle Tissue Regeneration
Regulation Of Sodium Ion Transport
Glucocorticoid Catabolic Process
Intracellular Protein Transport
Substantia Nigra Development
Glucocorticoid Receptor Signaling Pathway
Regulation Of Neuron Differentiation
Positive Regulation Of Transcription, DNA-templated
Regulation Of Synaptic Plasticity
Negative Regulation Of Dendrite Morphogenesis
Membrane Organization
Membrane Depolarization During Action Potential
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways
SCF(Skp2)-mediated degradation of p27/p21
AKT phosphorylates targets in the cytosol
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
RHO GTPases activate CIT
Constitutive Signaling by AKT1 E17K in Cancer
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Cyclin E associated events during G1/S transition
Cyclin D associated events in G1
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates Cell Cycle
FLT3 Signaling
FOXO-mediated transcription of cell cycle genes
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Activation of BAD and translocation to mitochondria
Translocation of SLC2A4 (GLUT4) to the plasma membrane
RHO GTPases activate PKNs
TP53 Regulates Metabolic Genes
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Drugs
Phenethyl Isothiocyanate
Diseases
Prostate cancer
GWAS
Appendicular lean mass (
33097823
)
Brain morphology (MOSTest) (
32665545
)
Diastolic blood pressure (
30487518
)
Mean arterial pressure (
29403010
30487518
)
Metabolite levels (
23823483
)
Monocyte percentage of white cells (
32888494
)
Mosaic loss of chromosome Y (Y chromosome dosage) (
31624269
)
Plateletcrit (
32888494
)
Prostate cancer (
31562322
29892016
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
23273568
)
Systolic blood pressure (
30487518
)
Type 2 diabetes (
30297969
)
Post bronchodilator FEV1 (
26634245
)
Type 2 diabetes (
30297969
)
Interacting Genes
73 interacting genes:
ABL1
AKT1
ARHGDIA
ARIH1
CAMK1
CASP8
CCNA1
CCNA2
CCNB1
CCND1
CCND2
CCND3
CCNE1
CCNE2
CDC34
CDK1
CDK2
CDK3
CDK4
CDK5
CKS1B
COP1
COPS5
CUL1
CUL4A
DCLRE1C
GRB2
H1-1
H1-5
IRF1
KAT2B
KPNA1
KPNA3
KPNA4
KPNA5
KPNA6
LYN
MAPK10
MCM7
MTUS2
MYC
NUP50
PIN1
PSMB1
RBX1
RCHY1
RNF123
RPS6KA1
SGK1
SIRT6
SKP1
SKP2
SPDYA
SRC
STMN1
TRAF2
TSC2
UBAC1
UBB
UBE2B
UBE2D2
UBE2I
UBE2L3
UBE3A
UCHL1
XPO1
YES1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
66 interacting genes:
ABL1
ARHGEF28
BAD
BCR
BRAF
CCDC125
CDC25B
CDC25C
CDC42
CDK16
CDKN1B
CHRNA4
CREBBP
EPB41L2
EPB41L3
ESR1
ESR2
EXO1
GREM1
HSPB1
ING1
KANK1
KCNH2
KCNK15
KCNK3
KCNK9
KIF5B
KLC3
KRT18
MAP3K3
MAP3K5
MARK4
MDM4
MED1
MST1R
NCOA1
NCOA2
NCOA3
NEK1
NHSL2
NR3C1
NRIP1
PARD3
PARD6A
PARD6B
PDPK1
PRKCI
PRKN
PTH1R
RAF1
REM1
RIMS1
RIMS2
RPH3A
SAMSN1
SNCA
SRC
THRA
TLX2
TNFAIP3
TPH1
TSC1
TSC2
YWHAE
YWHAG
ZFP36
Entrez ID
1027
7533
HPRD ID
02867
00215
Ensembl ID
ENSG00000111276
ENSG00000128245
Uniprot IDs
P46527
Q6I9V6
A0A024R1K7
Q04917
Q9H4N8
PDB IDs
1H27
1JSU
2AST
5UQ3
6ATH
6P8E
6P8F
6P8G
2C63
2C74
Enriched GO Terms of Interacting Partners
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