CDKN1B and XPO1

Data Source:
HPRD (in vivo, in vitro)

		CDKN1B	XPO1
Description		cyclin dependent kinase inhibitor 1B	exportin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Cul4A-RING E3 Ubiquitin Ligase Complex Intracellular Membrane-bounded Organelle	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin Binding Protein-containing Complex Binding Chaperone Binding	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Cellular Response To Lithium Ion Mitotic Cell Cycle Arrest Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Protein Export From Nucleus Nucleocytoplasmic Transport Viral Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Biogenesis Regulation Of MRNA Stability MRNA Transport Intracellular Transport Of Virus
Pathways		SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation
Drugs			Selinexor
Diseases		Prostate cancer
GWAS		Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 31562322 29892016) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)	Atrial fibrillation ( 29892015) Eosinophil counts ( 32888494 27863252) Erectile dysfunction ( 30583798) Mean reticulocyte volume ( 32888494) Neutrophil count ( 32888494) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800) White blood cell count ( 32888494)
Interacting Genes		73 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE1 CCNE2 CDC34 CDK1 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL1 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RBX1 RCHY1 RNF123 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2I UBE2L3 UBE3A UCHL1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	80 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDC42 CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 LINC01554 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 SUMO2 TERF2IP TERT TOP2A TOP2B TP53 TP73
Entrez ID		1027	7514
HPRD ID		02867	03975
Ensembl ID		ENSG00000111276	ENSG00000082898
Uniprot IDs		P46527 Q6I9V6	B3KWD0 O14980
PDB IDs		1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G	1W9C 2L1L 3GB8 4BSM 4BSN 5DIS 6TVO
Enriched GO Terms of Interacting Partners?
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