IRX5 and APLF

Data Source:
HPRD (in vitro)

		IRX5	APLF
Description		iroquois homeobox 5	aprataxin and PNKP like factor
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Cytosol Site Of Double-strand Break
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Vitamin D Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding 3'-5' Exonuclease Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Visual Perception Gonad Development Neuron Differentiation Cell Development Embryonic Cranial Skeleton Morphogenesis Response To Stimulus	Single Strand Break Repair Double-strand Break Repair Cellular Response To DNA Damage Stimulus Positive Regulation Of DNA Ligation Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases
GWAS		Dialysis-related mortality ( 21546767) Heel bone mineral density ( 30598549 28869591) Hypospadias ( 25108383) Refractive error ( 32231278) Social communication problems ( 24564958) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	Restless legs syndrome ( 29029846) Urate levels in lean individuals ( 25811787)
Interacting Genes		1 interacting genes: APLF	7 interacting genes: APP FBXO25 GMCL1 IRX5 LIG4 XRCC1 XRCC4
Entrez ID		10265	200558
HPRD ID		08395	09848
Ensembl ID		ENSG00000176842	ENSG00000169621
Uniprot IDs		P78411	Q8IW19
PDB IDs			2KQB 2KQC 2KQD 2KQE 2KUO 5E50 5W7W 5W7X 5W7Y 6ERF 6TYT 6TYW 6TYZ
Enriched GO Terms of Interacting Partners?
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