AP3S2 and SCARB2

Data Source:
BioGRID (pull down)

		AP3S2	SCARB2
Description		adaptor related protein complex 3 subunit sigma 2	scavenger receptor class B member 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus AP-3 Adaptor Complex Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle Axon Cytoplasm	Golgi Membrane Cytoplasm Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Endosome Membrane Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane Endocytic Vesicle Membrane Late Endosome Membrane Lysosomal Lumen Extracellular Exosome
	Molecular Function		Virus Receptor Activity Phosphatidylserine Binding Transmembrane Signaling Receptor Activity Scavenger Receptor Activity Protein Binding Cholesterol Binding Enzyme Binding Phosphatidylcholine Binding Cargo Receptor Activity Protein Homodimerization Activity
	Biological Process	Intracellular Protein Transport Anterograde Axonal Transport Vesicle-mediated Transport Anterograde Synaptic Vesicle Transport	Protein Targeting To Lysosome Receptor-mediated Endocytosis Positive Regulation Of Neuron Projection Development Aminophospholipid Transport Regulation Of Cellular Carbohydrate Catabolic Process Viral Entry Into Host Cell Membrane Organization Regulation Of Endosome Organization Regulation Of Glucosylceramidase Activity Regulation Of Lysosome Organization
Pathways			Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Type 2 diabetes ( 24509480 30054458 21874001 29358691 30297969 23945395 32499647 30718926 28869590)	BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Estimated glomerular filtration rate ( 31015462) Hippocampal volume ( 29274321) Parkinson's disease ( 25064009 21738487) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		7 interacting genes: AP3B1 AP3D1 AP3S1 ARF1 ARF6 E2F4 SCARB2	10 interacting genes: AP3S1 AP3S2 CLDN19 ERGIC3 GPR37L1 GPX8 HIBADH LAPTM4B LMNA THBS1
Entrez ID		10239	950
HPRD ID		03880	03772
Ensembl ID		ENSG00000157823	ENSG00000138760
Uniprot IDs		A0A024RC62 P59780	A0A024RDG6 Q14108
PDB IDs			4F7B 4Q4B 4Q4F 4TVZ 4TW0 4TW2 5UPH 5XBM 6I2K
Enriched GO Terms of Interacting Partners?
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