GDF11 and ACVR2B

Data Source:
HPRD (in vivo, in vitro)

		GDF11	ACVR2B
Description		growth differentiation factor 11	activin A receptor type 2B
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GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Protein Binding Growth Factor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Skeletal System Development Metanephros Development Ureteric Bud Development Nervous System Development Mesoderm Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spinal Cord Anterior/posterior Patterning Pancreas Development Negative Regulation Of Neuron Differentiation Cell Maturation Camera-type Eye Morphogenesis Roof Of Mouth Development SMAD Protein Signal Transduction	Negative Regulation Of Transcription By RNA Polymerase II Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Bone Mineralization BMP Signaling Pathway Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Positive Regulation Of Osteoblast Differentiation Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways			Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Refractive error ( 32231278)	Bitter beverage consumption ( 31046077) Body size at age 10 ( 32376654) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		1 interacting genes: ACVR2B	21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1
Entrez ID		10220	93
HPRD ID		04895	04106
Ensembl ID		ENSG00000135414	ENSG00000114739
Uniprot IDs		A0A024RB20 O95390	Q13705
PDB IDs		5E4G 5JHW 5UHM 6MAC	2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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