AASS and ARF5

Data Source:
BioGRID (affinity chromatography technology)

		AASS	ARF5
Description		aminoadipate-semialdehyde synthase	ADP ribosylation factor 5
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Intracellular Membrane-bounded Organelle	Cytoplasm Golgi Apparatus Plasma Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Saccharopine Dehydrogenase Activity Saccharopine Dehydrogenase (NAD+, L-lysine-forming) Activity Histone Binding Saccharopine Dehydrogenase (NADP+, L-lysine-forming) Activity Saccharopine Dehydrogenase (NAD+, L-glutamate-forming) Activity	GTPase Activity Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Lysine Catabolic Process Lysine Biosynthetic Process Via Aminoadipic Acid Negative Regulation Of Histone Methylation L-lysine Catabolic Process To Acetyl-CoA Via Saccharopine	Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Vesicle-mediated Transport
Pathways		Lysine catabolism	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs		Glutamic acid NADH NADPH L-Saccharopine
Diseases		Hyperlysinemia
GWAS			Type 2 diabetes ( 23532257)
Interacting Genes			14 interacting genes: ACY3 AP1B1 AP3B1 ARFIP1 ARFIP2 ASAP2 DTX3 ERBB2 GGA1 GORAB IKBKG PIP5K1A RAB11A RAB11FIP3
Entrez ID		10157	381
HPRD ID		05489	00055
Ensembl ID		ENSG00000008311	ENSG00000004059
Uniprot IDs		A4D0W4 Q9UDR5	A4D0Z3 P84085
PDB IDs		5L76 5L78 5O1N 5O1O 5O1P	2B6H
Enriched GO Terms of Interacting Partners?
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