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TRIM28 and UBE2D2
Data Source:
BioGRID
(pull down, pull down)
TRIM28
UBE2D2
Description
tripartite motif containing 28
ubiquitin conjugating enzyme E2 D2
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Krueppel-associated Box Domain Binding
Chromo Shadow Domain Binding
Promoter-specific Chromatin Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Epithelial To Mesenchymal Transition
DNA Repair
Chromatin Organization
Transcription Initiation From RNA Polymerase II Promoter
Ras Protein Signal Transduction
Embryo Implantation
Viral Process
Protein Ubiquitination
Protein Sumoylation
Positive Regulation Of Protein Import Into Nucleus
DNA Methylation Involved In Embryo Development
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of DNA Repair
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Convergent Extension Involved In Axis Elongation
Embryonic Placenta Morphogenesis
Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Negative Regulation Of DNA Demethylation
Negative Regulation Of Viral Release From Host Cell
Regulation Of Genetic Imprinting
Protein Polyubiquitination
MyD88-independent Toll-like Receptor Signaling Pathway
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Targeting To Peroxisome
Protein Ubiquitination
TRIF-dependent Toll-like Receptor Signaling Pathway
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Pathways
Generic Transcription Pathway
SUMOylation of transcription cofactors
HCMV Early Events
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
(R,R)-2,3-Butanediol
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Alzheimer's disease (late onset) (
30820047
)
Body mass index (
26426971
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Leukocyte telomere length (
32109421
)
Interacting Genes
76 interacting genes:
CBX1
CBX3
CBX5
CDC34
CDC42
CDCA4
CDKN2A
CEBPB
CHAF1A
CHD3
ESR1
FBP1
FES
HDAC10
HTRA2
IRF1
IRF7
LYN
MAGEA2
MAGEA2B
MAGEA6
MAGED1
MAPKAPK2
MCM3
MCM5
MCM6
MYB
NPM1
NR3C1
NR4A1
NR4A3
NSMCE3
PCNA
PFDN5
PPP2CA
PTEN
RFC4
RNF4
SERTAD1
SERTAD2
SETDB1
SIN3A
SIRT1
SKI
SMARCAD1
SPG7
STAT3
SUMO2
TP73
TRIM24
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
VHL
VIM
YWHAQ
ZNF10
ZNF133
ZNF140
ZNF197
ZNF354A
ZNF382
ZNF420
ZNF496
ZNF689
ZNF74
ZNF93
252 interacting genes:
AMFR
ANAPC11
ANAPC2
AREL1
ARIH2
ARRDC3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRAP
BRCA1
BTRC
CADPS2
CBL
CBLB
CBLC
CCNB1
CDKN1B
CHFR
CNOT4
COP1
CUEDC1
CUL3
CYLD
DCAF1
DDX58
DLST
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL17
FBXL3
FBXO2
FBXO4
FBXO7
FBXW2
FOXO1
G0S2
H3C1
H4C1
HACE1
HECTD1
HECTD3
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC4
HERC5
HUWE1
ILF3
ITCH
KAT2B
KCMF1
LNX1
LNX2
LRSAM1
LTN1
MAEA
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF6
MARCHF7
MDM2
MDM4
MEX3A
MEX3C
MGRN1
MIB1
MIB2
MID1
MID2
MKRN3
MUL1
MYCBP2
MYLIP
NAT10
NBR1
NEDD4
NEDD4L
NFKBIA
NPR1
NSMCE1
OTUB1
PDZRN3
PELI1
PER2
PHF7
PHRF1
PJA1
PJA2
POLL
POLM
PRKN
QSOX1
RAD18
RAF1
RAG1
RBCK1
RBX1
RC3H1
RC3H2
RCHY1
RELA
RFFL
RFWD3
RING1
RLIM
RMND5A
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF125
RNF126
RNF13
RNF130
RNF135
RNF138
RNF14
RNF146
RNF150
RNF151
RNF166
RNF167
RNF168
RNF170
RNF181
RNF185
RNF186
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF224
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF40
RNF43
RNF5
RNF7
RNF8
RSPRY1
RTF2
SIAH1
SIAH2
SMURF1
SMURF2
SNCA
SOCS6
SPOP
SQSTM1
STAM2
STK11
STUB1
SYVN1
TOPORS
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM35
TRIM36
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM46
TRIM47
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM65
TRIM7
TRIM8
TRIP12
TTC3
UBA1
UBA3
UBA5
UBA6
UBASH3B
UBB
UBC
UBD
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR1
UBR2
UBR3
UBR4
UBR5
UBTD1
UFM1
UHRF2
UVSSA
VHL
VPS11
VPS18
WRN
WSB1
WWP1
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
Entrez ID
10155
7322
HPRD ID
03445
04268
Ensembl ID
ENSG00000130726
ENSG00000131508
Uniprot IDs
Q13263
P62837
PDB IDs
1FP0
2RO1
2YVR
6H3A
6I9H
6QAJ
6QU1
1UR6
1W4U
2CLW
2ESK
2ESO
2ESP
2ESQ
3A33
3JVZ
3JW0
3L1Y
3TGD
3ZNI
4A49
4A4B
4A4C
4AUQ
4DDG
4DDI
4LDT
4V3K
4V3L
4WZ3
5D0K
5D0M
5D1K
5D1L
5D1M
5EDV
5MNJ
5ULF
5ULH
5ULK
5VZW
5ZBU
6HPR
6SQO
6SQR
6SQS
6TTU
6W7Z
6W9D
Enriched GO Terms of Interacting Partners
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