G3BP1 and SYNPO

Data Source:
BioGRID (affinity chromatography technology)

		G3BP1	SYNPO
Description		G3BP stress granule assembly factor 1	synaptopodin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon Ribonucleoprotein Complex	Stress Fiber Nucleus Cytosol Bicellular Tight Junction Postsynaptic Density Actin Cytoskeleton Z Disc Dendritic Spine Perikaryon Spine Apparatus
	Molecular Function	DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Endonuclease Activity Protein Binding ATP Binding DNA/RNA Helicase Activity	Actin Binding Protein Binding
	Biological Process	Ras Protein Signal Transduction Viral Process DNA Duplex Unwinding Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Nucleic Acid Phosphodiester Bond Hydrolysis	Positive Regulation Of Actin Filament Bundle Assembly Modification Of Dendritic Spine Spine Apparatus Assembly
Pathways
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)	Cholangiocarcinoma in primary sclerosing cholangitis ( 28779025) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401)
Interacting Genes		12 interacting genes: APP CSK DTX1 EPHA8 FBXO25 IL7R LCK LINC01554 PIN1 PPIA RASA1 USP10	8 interacting genes: CDC5L MAGI1 NCK1 NCK2 NONO SGF29 YWHAG YWHAZ
Entrez ID		10146	11346
HPRD ID		06569	12179
Ensembl ID		ENSG00000145907	ENSG00000171992
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	Q8N3V7
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5
Enriched GO Terms of Interacting Partners?
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