IL18BP and IL18

Data Source:
HPRD (in vivo, in vitro)

		IL18BP	IL18
Description		interleukin 18 binding protein	interleukin 18
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome	Extracellular Region Extracellular Space Cytosol
	Molecular Function	Interleukin-18 Binding Receptor Antagonist Activity	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding
	Biological Process	Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Cellular Response To Cytokine Stimulus Negative Regulation Of Signaling Receptor Activity	MAPK Cascade Angiogenesis Inflammatory Response Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase B Activity Chemokine Production Interferon-gamma Production Interleukin-13 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Triglyceride Homeostasis Cellular Response To Organic Cyclic Compound Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production
Pathways		Interleukin-37 signaling Interleukin-18 signaling	Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection
Drugs
Diseases
GWAS			Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		2 interacting genes: IL18 IL37	9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2
Entrez ID		10068	3606
HPRD ID		04984	02976
Ensembl ID		ENSG00000137496	ENSG00000150782
Uniprot IDs		A0A024R5G2 A0A024R5I1 A0A024R5M7 G3V1C5 O95998	A0A024R3E0 Q14116
PDB IDs			1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU
Enriched GO Terms of Interacting Partners?
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