IL18 and ADIRF

Data Source:
BioGRID (two hybrid)

		IL18	ADIRF
Description		interleukin 18	adipogenesis regulatory factor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	Cytokine Activity Protein Binding Interleukin-18 Receptor Binding	Molecular_function Protein Binding
	Biological Process	MAPK Cascade Angiogenesis Inflammatory Response Cell-cell Signaling Cell Population Proliferation Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Cytokine-mediated Signaling Pathway Natural Killer Cell Activation Regulation Of Cell Adhesion Sleep Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase B Activity Chemokine Production Interferon-gamma Production Interleukin-13 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Tissue Remodeling Interleukin-18-mediated Signaling Pathway T-helper 1 Type Immune Response Type 2 Immune Response Positive Regulation Of Activated T Cell Proliferation Neutrophil Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Cholesterol Homeostasis Positive Regulation Of T-helper 2 Cell Differentiation Negative Regulation Of Myoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of NK T Cell Proliferation Positive Regulation Of Protein Kinase B Signaling Triglyceride Homeostasis Cellular Response To Organic Cyclic Compound Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Neuroinflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of T-helper 1 Cell Cytokine Production	Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Radiation Cellular Response To Cisplatin Regulation Of Response To Drug
Pathways		Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-18 signaling Purinergic signaling in leishmaniasis infection	Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Blood protein levels in cardiovascular risk ( 28369058) Inflammatory biomarkers ( 24182552) Interleukin-18 levels ( 27989323 31584380) Protein quantitative trait loci ( 18464913)
Interacting Genes		9 interacting genes: ADIRF CASK CASP1 CASP3 CASP4 IL18BP IL18R1 IL18RAP IL1RL2	3 interacting genes: GSK3B IL18 RPS6KA6
Entrez ID		3606	10974
HPRD ID		02976	16575
Ensembl ID		ENSG00000150782	ENSG00000148671
Uniprot IDs		A0A024R3E0 Q14116	Q15847 Q5TBU5
PDB IDs		1J0S 2VXT 3F62 3WO2 3WO3 3WO4 4EEE 4EKX 4HJJ 4R6U 4XFS 4XFT 4XFU
Enriched GO Terms of Interacting Partners?
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