GJC1 and TMEM86A

Data Source:
BioGRID (two hybrid)

		GJC1	TMEM86A
Description		gap junction protein gamma 1	transmembrane protein 86A
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Gap Junction Connexin Complex Intercalated Disc Integral Component Of Membrane Synapse	Integral Component Of Membrane
	Molecular Function	Ion Channel Activity Gap Junction Channel Activity Protein Binding Gap Junction Channel Activity Involved In SA Node Cell-atrial Cardiac Muscle Cell Electrical Coupling Gap Junction Channel Activity Involved In AV Node Cell-bundle Of His Cell Electrical Coupling	Protein Binding Alkenylglycerophosphocholine Hydrolase Activity Alkenylglycerophosphoethanolamine Hydrolase Activity
	Biological Process	Vasculogenesis Muscle Contraction Cell-cell Junction Assembly Cell-cell Signaling Chemical Synaptic Transmission Visual Perception Gap Junction Assembly Ion Transmembrane Transport Cell Development Cardiac Muscle Tissue Development Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication By Electrical Coupling AV Node Cell To Bundle Of His Cell Communication By Electrical Coupling
Pathways		Electric Transmission Across Gap Junctions Gap junction assembly
Drugs
Diseases
GWAS			Ovarian reserve ( 22116950)
Interacting Genes		8 interacting genes: APOL3 CNST MEOX2 SLC66A1 TJP1 TJP3 TMEM86A UBQLN4	47 interacting genes: AQP2 AQP3 BCL2L13 CD79A CISD2 CNR2 COQ9 CPLX4 CREB3L1 EBP ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 FXYD3 GJB4 GJB5 GJC1 GORAB GPR37L1 HAVCR2 KASH5 KCNA1 LHFPL5 LMNA MS4A2 MUC1 NCAPH2 PDZK1IP1 PGRMC2 PI16 REEP4 RIC3 RNF185 SCN3B SLC10A6 SLC18A1 SLC30A2 SLC35C2 SLC39A2 SSMEM1 THAP4 TIMMDC1 TMEM31 TMPRSS2 TYROBP
Entrez ID		10052	144110
HPRD ID		08819	08292
Ensembl ID		ENSG00000182963	ENSG00000151117
Uniprot IDs		A0A654IDC0 P36383	Q8N2M4
PDB IDs		3SHW
Enriched GO Terms of Interacting Partners?
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