TOM1 and ZFYVE16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro, two hybrid)

		TOM1	ZFYVE16
Description		target of myb1 membrane trafficking protein	zinc finger FYVE-type containing 16
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane Extracellular Exosome	Early Endosome Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Clathrin Binding	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Signal Transduction Protein Transport Endosomal Transport Neutrophil Degranulation	Protein Targeting To Lysosome Signal Transduction Vesicle Organization Endosomal Transport Regulation Of Endocytosis BMP Signaling Pathway
Pathways		Neutrophil degranulation	Signaling by BMP
Drugs
Diseases
GWAS		Cholesterol, total ( 24097068) HDL cholesterol ( 29404214) High density lipoprotein cholesterol levels ( 31217584) Hippocampal volume in mild cognitive impairment ( 29274321) Inflammatory bowel disease ( 28067908) Low density lipoprotein cholesterol levels ( 32154731) Multiple myeloma ( 26007630) Multiple myeloma and monoclonal gammopathy ( 26007630) Plasma proprotein convertase subtilisin/kexin type 9 levels in stable coronary artery disease ( 29748315) Total cholesterol levels ( 28334899) Ulcerative colitis ( 28067908) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blond vs. brown/black hair color ( 30531825) Psoriasis ( 25854761)
Interacting Genes		21 interacting genes: APP CLTC DAZAP2 EEA1 ILVBL LITAF LRRC20 MAP3K1 MYO6 NAA11 NEDD4 PILRA PTBP2 RPS27 SMURF1 SSBP2 TOLLIP UBC UBE2D1 ZFYVE16 ZNF512B	5 interacting genes: APP EEA1 PPP1CA RNF11 TOM1
Entrez ID		10043	9765
HPRD ID		05265	10319
Ensembl ID		ENSG00000100284	ENSG00000039319
Uniprot IDs		B3KUF5 O60784	Q7Z3T8
PDB IDs		1ELK 1WRD 2N2N 2N9D 6J56	3T7L 5MK0
Enriched GO Terms of Interacting Partners?
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