ZFYVE16 and EEA1

Data Source:
HPRD (in vitro)

		ZFYVE16	EEA1
Description		zinc finger FYVE-type containing 16	early endosome antigen 1
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GO Annotations	Cellular Component	Early Endosome Cytosol Early Endosome Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome
	Molecular Function	Protein Binding 1-phosphatidylinositol Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Metal Ion Binding	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Targeting To Lysosome Signal Transduction Vesicle Organization Endosomal Transport Regulation Of Endocytosis BMP Signaling Pathway	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Viral RNA Genome Replication Early Endosome To Late Endosome Transport
Pathways		Signaling by BMP	Toll Like Receptor 9 (TLR9) Cascade
Drugs			Inositol 1,3-Bisphosphate
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Psoriasis ( 25854761)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)
Interacting Genes		5 interacting genes: APP EEA1 PPP1CA RNF11 TOM1	13 interacting genes: IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 ZFYVE16
Entrez ID		9765	8411
HPRD ID		10319	05460
Ensembl ID		ENSG00000039319	ENSG00000102189
Uniprot IDs		Q7Z3T8	Q15075
PDB IDs		3T7L 5MK0	1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?
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