MAP3K8

Description		mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle T Cell Costimulation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Novel Interacting Genes		9 novel interacting genes: ACP6 ADAM10 GAD2 JCAD LYZL2 MTPAP PARD3 PDK2 RANGAP1
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		1326
HPRD ID		01863
Ensembl ID		ENSG00000107968
Uniprot IDs		P41279 Q6FG25
PDB IDs		4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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