MAP3K8 and ACP6

Data Source:
BioGRID (genetic interference)

		MAP3K8	ACP6
Description		mitogen-activated protein kinase kinase kinase 8	acid phosphatase 6, lysophosphatidic
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GO Annotations	Cellular Component	Cytosol	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Acid Phosphatase Activity Phosphatase Activity Lysophosphatidic Acid Phosphatase Activity
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle T Cell Costimulation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	Hematopoietic Progenitor Cell Differentiation Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Dephosphorylation Lysobisphosphatidic Acid Metabolic Process
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation	Synthesis of PA
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Blood protein levels ( 30072576) Methotrexate-induced interstitial lung disease in rheumatoid arthritis ( 28500057)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	3 interacting genes: FAM9B GNG7 SLC35F6
Entrez ID		1326	51205
HPRD ID		01863	16472
Ensembl ID		ENSG00000107968	ENSG00000162836
Uniprot IDs		P41279 Q6FG25	Q9NPH0
PDB IDs		4Y83 4Y85 5IU2	4JOB 4JOC 4JOD
Enriched GO Terms of Interacting Partners?
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