MAP3K8 and MTPAP

Data Source:
BioGRID (affinity chromatography technology)

		MAP3K8	MTPAP
Description		mitogen-activated protein kinase kinase kinase 8	mitochondrial poly(A) polymerase
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GO Annotations	Cellular Component	Cytosol	Nucleoplasm Mitochondrion Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding	Magnesium Ion Binding UTP Binding RNA Binding Polynucleotide Adenylyltransferase Activity Protein Binding ATP Binding Nucleotidyltransferase Activity Manganese Ion Binding Identical Protein Binding Protein Homodimerization Activity RNA Adenylyltransferase Activity
	Biological Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle T Cell Costimulation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway	MRNA Polyadenylation RNA 3'-end Processing Histone MRNA Catabolic Process
Pathways		CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Asthma ( 32296059) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)	Paclitaxel disposition in epithelial ovarian cancer ( 29367611)
Interacting Genes		17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6	3 interacting genes: AZI2 CALCOCO2 TBK1
Entrez ID		1326	55149
HPRD ID		01863	15097
Ensembl ID		ENSG00000107968	ENSG00000107951
Uniprot IDs		P41279 Q6FG25	Q9NVV4
PDB IDs		4Y83 4Y85 5IU2	3PQ1
Enriched GO Terms of Interacting Partners?
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