KMT2B and RPP14

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		KMT2B	RPP14
Description		lysine methyltransferase 2B	ribonuclease P/MRP subunit p14
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex
	Molecular Function	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding
	Biological Process	Histone H3-K4 Dimethylation Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K4 Monomethylation	TRNA 5'-leader Removal RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Height ( 28552196) Hemoglobin levels ( 32327693) Mitochondrial heteroplasmy measurement ( 33731350) Platelet distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	22 interacting genes: A2M ACTN2 ATP5F1B CAPZB DOCK7 EXOSC8 GEMIN2 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ ZNF277
Entrez ID		9757	11102
HPRD ID		06017	18001
Ensembl ID		ENSG00000272333	ENSG00000163684
Uniprot IDs		Q9UMN6	O95059
PDB IDs		3UVM 4ERZ 4PZI 7BRE	6AHR 6AHU
Enriched GO Terms of Interacting Partners?
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