KMT2B and ASH2L

Number of citations of the paper that reports this interaction (PubMedID 24981860)
22

Data Source:
BioGRID (pull down, affinity chromatography technology, proximity labelling technology)

		KMT2B	ASH2L
Description		lysine methyltransferase 2B	ASH2 like, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex
	Molecular Function	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding	Transcription Cis-regulatory Region Binding Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding
	Biological Process	Histone H3-K4 Dimethylation Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K4 Monomethylation	Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Population Proliferation Hemopoiesis Response To Estrogen Histone H3-K4 Methylation
Pathways		PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)	Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656) Venous thromboembolism ( 33592630)
Interacting Genes		27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B	37 interacting genes: ACTC1 ACTN2 ANKRD1 ATP1A3 BARD1 BRCA1 CCNC CEP76 CHD8 COPS6 CTNNB1 DNMT3L DPY30 EP300 FURIN H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 MESD MKRN1 MYBPC1 MYOM3 PPP1CC PRMT1 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 TTN UNC119 WWP1 ZSCAN1
Entrez ID		9757	9070
HPRD ID		06017	05309
Ensembl ID		ENSG00000272333	ENSG00000129691
Uniprot IDs		Q9UMN6	B4DPT1 F5H8F7 Q9UBL3
PDB IDs		3UVM 4ERZ 4PZI 7BRE	3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ 6PWV 7BRE
Enriched GO Terms of Interacting Partners?
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