RPP14 and A2M

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RPP14	A2M
Description		ribonuclease P/MRP subunit p14	alpha-2-macroglobulin
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Growth Factor Binding Enzyme Binding Interleukin-8 Binding Interleukin-1 Binding Tumor Necrosis Factor Binding Calcium-dependent Protein Binding
	Biological Process	TRNA 5'-leader Removal RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Endopeptidase Activity Stem Cell Differentiation
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Degradation of the extracellular matrix HDL assembly
Drugs			Becaplermin Cisplatin Bacitracin Zinc Ocriplasmin Silver Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Height ( 28552196) Hemoglobin levels ( 32327693) Mitochondrial heteroplasmy measurement ( 33731350) Platelet distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)	Refractive error ( 32231278)
Interacting Genes		22 interacting genes: A2M ACTN2 ATP5F1B CAPZB DOCK7 EXOSC8 GEMIN2 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ ZNF277	98 interacting genes: ACTB ADAM19 ADAMTS1 AMBP ANXA6 ANXA7 AP1M2 APOE APP ATF7IP ATP1A1 B2M C11orf58 CDC37 CDC42 CDK2AP2 CDKN1A CELA1 CPB2 CTSB CTSE CYP2C18 CYP2C8 DNAJB1 ECSIT EGLN2 ELAVL3 ENO2 EVI5L EXOSC1 FARSA FBXL12 FBXW4 FIS1 GCDH GEM GRB2 H2AX HMOX2 HSP90AA1 HSPA5 HSPB2 IFIT3 IFIT5 IGSF8 IL10 IL1B IL4 KLK1 KLK13 KLK2 KLK3 LCAT LEP LINC02582 LONP1 LRP1 LYZ MAST1 MLST8 MMP2 MYOC NCDN NGF NOS3 NUDT21 OGA PAEP PAXIP1 PDGFA PDGFB PRAM1 PRDX2 RAB3A RAD23A RAP1B RETN RHEB RNF32 RPP14 SEPTIN8 SHBG SLC6A4 SMN1 STAMBPL1 SWSAP1 TGFBI TGIF1 TGM2 TK1 TNFRSF14 TRAPPC5 TSC22D1 TTR TUBA1B TYRO3 UFD1 UMPS
Entrez ID		11102	2
HPRD ID		18001	00072
Ensembl ID		ENSG00000163684	ENSG00000175899
Uniprot IDs		O95059	P01023
PDB IDs		6AHR 6AHU	1BV8 2P9R 4ACQ
Enriched GO Terms of Interacting Partners?
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