RPP14 and KMT2B

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		RPP14	KMT2B
Description		ribonuclease P/MRP subunit p14	lysine methyltransferase 2B
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GO Annotations	Cellular Component	Nucleoplasm Nucleolus Multimeric Ribonuclease P Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex
	Molecular Function	Ribonuclease P Activity Protein Binding Ribonuclease P RNA Binding	Protein Binding Zinc Ion Binding Histone Methyltransferase Activity (H3-K4 Specific) Unmethylated CpG Binding
	Biological Process	TRNA 5'-leader Removal RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Histone H3-K4 Dimethylation Positive Regulation Of Transcription, DNA-templated Histone H3-K4 Methylation Histone H3-K4 Monomethylation
Pathways		tRNA processing in the nucleus Major pathway of rRNA processing in the nucleolus and cytosol	PKMTs methylate histone lysines RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Height ( 28552196) Hemoglobin levels ( 32327693) Mitochondrial heteroplasmy measurement ( 33731350) Platelet distribution width ( 32888494) Refractive error ( 32231278) Rheumatoid arthritis (ACPA-positive) ( 24532676) Total cholesterol levels ( 30275531)	Brain morphology (MOSTest) ( 32665545) Eosinophil percentage of white cells ( 32888494) Refractive error ( 32231278)
Interacting Genes		22 interacting genes: A2M ACTN2 ATP5F1B CAPZB DOCK7 EXOSC8 GEMIN2 IGSF21 KMT2B LIMD1 MSH2 NOVA1 PKM POP4 POP5 PSME1 RPP25 RPP30 RPP38 RPP40 WIZ ZNF277	27 interacting genes: ANXA1 ANXA7 ASH2L ATP1B1 ATXN1 CDKN1A GRB7 H3C1 H3C14 MTDH NREP PIK3R3 PIN1 PRPF40A RAP1B RBBP5 RCC1 RPP14 SEPTIN8 SMAD3 SMARCB1 SMN1 TK1 TRIM55 TRIM63 TSC22D1 ZNF512B
Entrez ID		11102	9757
HPRD ID		18001	06017
Ensembl ID		ENSG00000163684	ENSG00000272333
Uniprot IDs		O95059	Q9UMN6
PDB IDs		6AHR 6AHU	3UVM 4ERZ 4PZI 7BRE
Enriched GO Terms of Interacting Partners?
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