PPM1B and MAP3K7

Number of citations of the paper that reports this interaction (PubMedID 11104763)
50

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo, in vitro)

		PPM1B	MAP3K7
Description		protein phosphatase, Mg2+/Mn2+ dependent 1B	mitogen-activated protein kinase kinase kinase 7
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytosol Membrane	Nucleus Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Phosphatase Activity Protein Binding Manganese Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Receptor Tyrosine Kinase Binding Identical Protein Binding Scaffold Protein Binding Protein Serine Kinase Activity
	Biological Process	Protein Dephosphorylation N-terminal Protein Myristoylation Negative Regulation Of Interferon-beta Production Peptidyl-threonine Dephosphorylation Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Defense Response To Virus Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of NIK/NF-kappaB Signaling	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity I-kappaB Phosphorylation JNK Cascade Positive Regulation Of Macroautophagy Positive Regulation Of Interleukin-2 Production Fc-epsilon Receptor Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Anoikis Positive Regulation Of JUN Kinase Activity Histone H3 Acetylation T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		ISG15 antiviral mechanism ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants	Activation of NF-kappaB in B cells NOD1/2 Signaling Pathway Downstream TCR signaling FCERI mediated NF-kB activation Ca2+ pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Height ( 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Metabolite levels ( 23823483) Morning person ( 30696823) Number of sexual partners ( 30643258) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asthma ( 31959851 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Bone mineral density (hip) ( 30172743) Celiac disease ( 20190752) Cortical surface area ( 32963231) Cortical volume ( 32963231) Graves' disease ( 21841780) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Severity of nausea and vomiting of pregnancy ( 29563502)
Interacting Genes		22 interacting genes: AATK CDK2 CDK6 ECHS1 EGFR ERBB3 ERBB4 IKBKB IKBKG KDR MAD2L2 MAP3K7 MSN MYL7 NCOA1 PPARG PTK7 ROR1 ROR2 RYK SIRPA VAV2	71 interacting genes: AKTIP ATIC BBS10 BCL10 CALML6 CARD11 CHUK COPS5 CYLD EIF2AK2 ELP1 EZH2 FBXL4 FOS GPR25 HGS HIPK2 IKBKB IL17RD IRAK1 MAILR MAP2K4 MAP2K6 MAP3K14 MAP3K3 MAP3K5 MAP4K1 MAP4K4 MAPK14 MAPK6 MAPK8 MAPK8IP1 MAVS MUL1 NAIP NDUFS6 NFKBIA NOD2 NRIP1 PEBP1 PELI3 PINK1 PPM1B PPM1L PPP2R1A PPP5C PRKAB1 RBX1 RELA RNF19A ROR2 SMAD3 SMAD6 SMAD7 STAT3 STRADB SUPT20H TAB1 TAB2 TGFBR1 TNFRSF11A TRAF3 TRAF3IP2 TRAF6 UBASH3A UBC USP4 VRK2 XIAP ZNF593 ZNF746
Entrez ID		5495	6885
HPRD ID		04796	04011
Ensembl ID		ENSG00000138032	ENSG00000135341
Uniprot IDs		O75688	O43318
PDB IDs		2P8E	2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5V5N
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?