SPOP and HMGCS1

Number of citations of the paper that reports this interaction (PubMedID 28805822)
78

Data Source:
BioGRID (two hybrid)

		SPOP	HMGCS1
Description		speckle type BTB/POZ protein	3-hydroxy-3-methylglutaryl-CoA synthase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Cytoplasm Cytosol
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Hydroxymethylglutaryl-CoA Synthase Activity Isomerase Activity Protein Homodimerization Activity Organic Acid Binding
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Liver Development Acetyl-CoA Metabolic Process Lipid Metabolic Process Cholesterol Biosynthetic Process Brain Development Male Gonad Development Response To Xenobiotic Stimulus Response To Low Light Intensity Stimulus Farnesyl Diphosphate Biosynthetic Process, Mevalonate Pathway Response To Purine-containing Compound Response To Vitamin E Response To Tellurium Ion Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus
Pathways		Hedgehog 'on' state	Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs			(7R,12R,13R)-13-formyl-12,14-dihydroxy-3,5,7-trimethyltetradeca-2,4-dienoic acid
Diseases
GWAS		Prostate cancer ( 23535732)
Interacting Genes		68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	2 interacting genes: OGT SPOP
Entrez ID		8405	3157
HPRD ID		16004	07515
Ensembl ID		ENSG00000121067	ENSG00000112972
Uniprot IDs		O43791	A0A024R059 Q01581
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D	2P8U
Enriched GO Terms of Interacting Partners?
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