SPOP and DHX15

Number of citations of the paper that reports this interaction (PubMedID 28805822)
78

Data Source:
BioGRID (two hybrid)

		SPOP	DHX15
Description		speckle type BTB/POZ protein	DEAH-box helicase 15
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Intracellular Anatomical Structure Nucleus Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex Nucleolus Nuclear Speck
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	RNA Binding RNA Helicase Activity Double-stranded RNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	MRNA Processing RNA Splicing Response To Toxic Substance Response To Alkaloid
Pathways		Hedgehog 'on' state	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549) Myopia (pathological) ( 23049088) Pulmonary emphysema ( 24383474) Sense of smell ( 26632684)
Interacting Genes		68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	21 interacting genes: AGGF1 APBB1 CAMSAP3 DDX42 DYSF FXR1 GPANK1 KRT75 NKAP NKRF PIN1 PRPF40A PTEN RBM17 SPOP TRA2A UBC WBP4 YWHAB YWHAG ZGPAT
Entrez ID		8405	1665
HPRD ID		16004	04553
Ensembl ID		ENSG00000121067	ENSG00000109606
Uniprot IDs		O43791	O43143
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D	5XDR 6ID1 6SH6 6SH7
Enriched GO Terms of Interacting Partners?
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