SPOP and EGLN2

Number of citations of the paper that reports this interaction (PubMedID 28089830)
17

Data Source:
BioGRID (pull down, pull down)

		SPOP	EGLN2
Description		speckle type BTB/POZ protein	egl-9 family hypoxia inducible factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Cul3-RING Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding	Protein Binding Ferrous Iron Binding 2-oxoglutarate-dependent Dioxygenase Activity Oxygen Sensor Activity L-ascorbic Acid Binding Peptidyl-proline Dioxygenase Activity Peptidyl-proline 4-dioxygenase Activity
	Biological Process	Protein Polyubiquitination Regulation Of Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Regulation Of Cell Growth Response To Hypoxia Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Intracellular Estrogen Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process Cell Redox Homeostasis Positive Regulation Of Protein Catabolic Process Cellular Response To Hypoxia
Pathways		Hedgehog 'on' state	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Drugs			Ascorbic acid Roxadustat
Diseases
GWAS		Prostate cancer ( 23535732)	Alanine aminotransferase levels ( 33547301) Carotid intima media thickness (mean) ( 31801372) Chronic obstructive pulmonary disease ( 22080838) Chronic obstructive pulmonary disease in current smokers ( 33106845) Chronic obstructive pulmonary disease x current smoker interaction (2df) ( 33106845) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Nicotine metabolite ratio in current smokers ( 28921760) Parental longevity (father's attained age) ( 29227965) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Red blood cell count ( 32888494) Serum alkaline phosphatase levels ( 33547301) Smoking behavior ( 20418890) Smoking behaviour (cigarettes smoked per day) ( 30617275)
Interacting Genes		68 interacting genes: AEN AMOTL2 AR ARIH1 BRD2 BRD3 BRMS1 CACUL1 CBX4 CCNE1 CDK4 CHAF1A CHD3 CREB5 CTDSPL2 CUL3 DAXX DDIT3 DHX15 DPPA2 EGLN2 ERF ERG FAF1 GATAD2A GCC1 GCC2 GIT2 GLI2 GMEB1 HCST HMGCS1 ILF3 INF2 IRF1 KPNA5 LRCH4 MACROH2A1 MRE11 MYD88 NANOG NCOA3 NUDCD3 PDX1 PIAS1 PIAS3 RANBP9 RBFOX2 RBPJ RPRD2 RTN3 RXRB SETD2 SRRM1 SUMO1 TCOF1 TOPORS TRAF1 TRAF6 UBE2D1 UBE2D2 UBE2E3 UBE2I VPS9D1-AS1 YWHAG ZBTB16 ZCCHC12 ZMYND8	11 interacting genes: A2M CDK2 EPAS1 HIF1A HIF3A MFHAS1 MOB4 PRKCA SPOP SRPK2 TENT5A
Entrez ID		8405	112398
HPRD ID		16004	06970
Ensembl ID		ENSG00000121067	ENSG00000269858
Uniprot IDs		O43791	A0A024R0R2 Q96KS0
PDB IDs		2CR2 3HQH 3HQI 3HQL 3HQM 3HSV 3HTM 3HU6 3IVB 3IVQ 3IVV 4EOZ 4HS2 4J8Z 4O1V 6F8F 6F8G 6I41 6I5P 6I68 6I7A 7D3D	5V1B
Enriched GO Terms of Interacting Partners?
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