CLPP and P4HA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CLPP	P4HA3
Description		caseinolytic mitochondrial matrix peptidase proteolytic subunit	prolyl 4-hydroxylase subunit alpha 3
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Endopeptidase Clp Complex	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Endopeptidase Activity ATP-dependent Peptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Identical Protein Binding ATPase Binding	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding L-ascorbic Acid Binding
	Biological Process	Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Membrane Protein Proteolysis Proteolysis Involved In Cellular Protein Catabolic Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline
Pathways			Collagen biosynthesis and modifying enzymes
Drugs		N-Formylmethionine
Diseases
GWAS			Hippocampal atrophy ( 25625606)
Interacting Genes		19 interacting genes: ABI2 C14orf119 CHCHD3 CLPX DTX2 EFEMP1 EFEMP2 GRN KRTAP10-1 NUTF2 P4HA3 PLSCR4 PPP2CA PSMB1 RBPMS STAT4 TNFSF9 TNPO3 TRIM54	50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A
Entrez ID		8192	283208
HPRD ID		03074	16413
Ensembl ID		ENSG00000125656	ENSG00000149380
Uniprot IDs		Q16740	Q7Z4N8
PDB IDs		1TG6 6BBA 6DL7 6H23
Enriched GO Terms of Interacting Partners?
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