P4HA3 and MSRA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		P4HA3	MSRA
Description		prolyl 4-hydroxylase subunit alpha 3	methionine sulfoxide reductase A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding L-ascorbic Acid Binding	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Cellular Protein Modification Process Methionine Metabolic Process Response To Oxidative Stress Protein Repair Cellular Response To Oxidative Stress
Pathways		Collagen biosynthesis and modifying enzymes	Protein repair
Drugs			1,4-Dithiothreitol
Diseases
GWAS		Hippocampal atrophy ( 25625606)	Adiposity ( 19557161) Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Alzheimer's disease ( 20452100) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Autoimmune thyroid disease ( 32581359) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Bipolar disorder ( 31043756) Bipolar disorder and schizophrenia ( 22688191) BMI x environmental factors (excluding physical activity) interaction ( 33654129) Body mass index ( 30108283 31453325) Body mass index variance ( 31453325) Body shape index ( 34021172) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Chronotype ( 26835600) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cooked vegetable consumption ( 32066663) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Depression ( 33859377) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 31152163) Feeling worry ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertension ( 19430479) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Joint mobility (Beighton score) ( 27182965) Liver enzyme levels (alanine transaminase) ( 33972514) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Myopia (pathological) ( 23049088) Neurociticism ( 29500382) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Schizophrenia ( 28991256 21679298 30285260 26198764) Serum metabolite levels ( 33031748) Smoking initiation (ever regular vs never regular) ( 30679032) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653 30578418) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference ( 30108283) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Weight ( 30108283)
Interacting Genes		50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A	14 interacting genes: ARID2 CCNI COPB2 COPS5 CTNNA3 EFCAB11 FARSB FBXL3 HPCAL4 HSPA4L P4HA3 SDHB SELENBP1 WDR44
Entrez ID		283208	4482
HPRD ID		16413	03152
Ensembl ID		ENSG00000149380	ENSG00000175806
Uniprot IDs		Q7Z4N8	Q9UJ68
PDB IDs
Enriched GO Terms of Interacting Partners?
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