P4HA3 and GGA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		P4HA3	GGA3
Description		prolyl 4-hydroxylase subunit alpha 3	golgi associated, gamma adaptin ear containing, ARF binding protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding L-ascorbic Acid Binding	Protein Binding Small GTPase Binding Phosphatidylinositol Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation
Pathways		Collagen biosynthesis and modifying enzymes	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS		Hippocampal atrophy ( 25625606)
Interacting Genes		50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A	38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		283208	23163
HPRD ID		16413	10443
Ensembl ID		ENSG00000149380	ENSG00000125447
Uniprot IDs		Q7Z4N8	A8K6M0 B7Z456 Q9NZ52
PDB IDs			1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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