P4HA3 and ACOT8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		P4HA3	ACOT8
Description		prolyl 4-hydroxylase subunit alpha 3	acyl-CoA thioesterase 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen	Peroxisomal Matrix Cytosol
	Molecular Function	Procollagen-proline 4-dioxygenase Activity Iron Ion Binding Protein Binding L-ascorbic Acid Binding	Acetyl-CoA Hydrolase Activity Succinyl-CoA Hydrolase Activity Protein Binding CoA Hydrolase Activity Palmitoyl-CoA Hydrolase Activity Choloyl-CoA Hydrolase Activity Glutaryl-CoA Hydrolase Activity Acetoacetyl-CoA Hydrolase Activity Acyl-CoA Hydrolase Activity Hydroxymethylglutaryl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity Medium-chain Acyl-CoA Hydrolase Activity Long-chain Acyl-CoA Hydrolase Activity Myristoyl-CoA Hydrolase Activity
	Biological Process	Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline	Acyl-CoA Metabolic Process Bile Acid Biosynthetic Process Fatty Acid Catabolic Process Peroxisome Fission Fatty Acid Beta-oxidation Using Acyl-CoA Oxidase Alpha-linolenic Acid Metabolic Process Dicarboxylic Acid Catabolic Process Negative Regulation Of CD4 Production
Pathways		Collagen biosynthesis and modifying enzymes	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol alpha-linolenic acid (ALA) metabolism Beta-oxidation of pristanoyl-CoA Beta-oxidation of very long chain fatty acids Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases
GWAS		Hippocampal atrophy ( 25625606)
Interacting Genes		50 interacting genes: ACOT8 ADRA2C ANAPC11 ATN1 B9D2 BAG4 BLOC1S2 C1orf112 C1QTNF2 CERCAM CKMT2 CLPP CT55 CTAG1A CTAG1B CTNNBIP1 DTNBP1 FAM136A GGA3 GPSM3 HGS KRTAP19-5 KRTAP6-1 KRTAP8-1 LRP2BP MAGEA2 MAGEA2B MAGEC2 MCCD1 MEOX2 MSRA NDN NICN1 NUTM1 OIP5 P4HB PROP1 PSMB4 RBFOX1 RUSC1 SCARA5 SERTAD1 SERTAD3 STMN3 TLE5 TOX2 VPS37C WDR62 ZBTB7B ZC3H12A	7 interacting genes: FBXO7 GRIN2A P4HA3 PEX5 PIK3CA PRDM16 REL
Entrez ID		283208	10005
HPRD ID		16413	06998
Ensembl ID		ENSG00000149380	ENSG00000101473
Uniprot IDs		Q7Z4N8	A0A494C0N6 O14734
PDB IDs
Enriched GO Terms of Interacting Partners?
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