TM4SF4 and TBXA2R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TM4SF4	TBXA2R
Description		transmembrane 4 L six family member 4	thromboxane A2 receptor
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Protein Binding	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	Tissue Regeneration	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Second-messenger-mediated Signaling Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Catalytic Activity Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Pathways			Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor
Drugs			Ridogrel Seratrodast Morniflumate
Diseases
GWAS		Alanine aminotransferase levels ( 33547301 33339817) Alanine transaminase levels ( 29403010) Gallstone disease ( 30504769 27094239) Gamma glutamyl transferase levels ( 29403010 33339817) Ischemic stroke (large artery atherosclerosis) ( 29531354) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Serum uric acid levels ( 30993211) Thyroid stimulating hormone levels ( 30367059 32769997) Urate levels ( 31578528)
Interacting Genes		22 interacting genes: APH1B CD79A CLEC17A CMTM2 CREB3 ERGIC3 FATE1 FFAR2 GJB1 GJB4 GJB5 GLP1R GPR101 GPR37L1 GPR42 GPX8 KCNK5 LHFPL5 OPRM1 SLC10A6 TBXA2R TMEM14B	35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MFSD5 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 TM4SF4 VRK2 YWHAZ ZDHHC15
Entrez ID		7104	6915
HPRD ID		07585	01768
Ensembl ID		ENSG00000169903	ENSG00000006638
Uniprot IDs		P48230	P21731 Q05C92 Q0VAB0
PDB IDs			1LBN
Enriched GO Terms of Interacting Partners?
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