TBXA2R and NOX1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TBXA2R	NOX1
Description		thromboxane A2 receptor	NADPH oxidase 1
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Early Endosome Plasma Membrane Cell Junction Cell Projection NADPH Oxidase Complex
	Molecular Function	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Voltage-gated Ion Channel Activity Protein Binding Superoxide-generating NAD(P)H Oxidase Activity Small GTPase Binding Metal Ion Binding NADP Binding
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Second-messenger-mediated Signaling Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Catalytic Activity Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Angiogenesis Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin NADP Metabolic Process Defense Response Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Positive Regulation Of Vascular Endothelial Growth Factor Production Cell Migration Extracellular Matrix Organization Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Superoxide Anion Generation Hydrogen Peroxide Metabolic Process Positive Regulation Of Integrin Biosynthetic Process Respiratory Burst Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Intracellular PH Elevation Cellular Response To Hyperoxia Oxygen Metabolic Process Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Cellular Stress Response To Acidic PH
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor	RHO GTPases Activate NADPH Oxidases CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs		Ridogrel Seratrodast Morniflumate	Oxygen
Diseases
GWAS
Interacting Genes		35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MFSD5 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 TM4SF4 VRK2 YWHAZ ZDHHC15	5 interacting genes: ARHGEF7 CYBA NOXA1 NOXO1 TBXA2R
Entrez ID		6915	27035
HPRD ID		01768	02203
Ensembl ID		ENSG00000006638	ENSG00000007952
Uniprot IDs		P21731 Q05C92 Q0VAB0	A6NGA6 Q1ZYL4 Q9Y5S8
PDB IDs		1LBN
Enriched GO Terms of Interacting Partners?
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