TBXA2R and ADIPOR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TBXA2R	ADIPOR1
Description		thromboxane A2 receptor	adiponectin receptor 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck	Plasma Membrane Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Thromboxane A2 Receptor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Protein Kinase Binding Signaling Receptor Activity Identical Protein Binding Metal Ion Binding Adiponectin Binding Adipokinetic Hormone Receptor Activity
	Biological Process	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Nutrient Response To Xenobiotic Stimulus Second-messenger-mediated Signaling Positive Regulation Of Blood Coagulation Response To Testosterone Thromboxane A2 Signaling Pathway Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Regulation Of Catalytic Activity Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis	Hormone-mediated Signaling Pathway Negative Regulation Of Epithelial Cell Migration Negative Regulation Of Epithelial To Mesenchymal Transition Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Fatty Acid Oxidation Negative Regulation Of Cell Growth Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Glucose Homeostasis Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of NIK/NF-kappaB Signaling
Pathways		Prostanoid ligand receptors G alpha (q) signalling events G alpha (12/13) signalling events Thromboxane signalling through TP receptor	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity
Drugs		Ridogrel Seratrodast Morniflumate
Diseases
GWAS			Mean platelet volume ( 32888494 27863252)
Interacting Genes		35 interacting genes: ADIPOR1 ARL6IP6 C5orf46 EMP1 GJB2 GNA11 GNA12 GNA13 GNAI2 GNAQ GNAS GNB1 GNG2 GPRASP1 GRK5 GRK6 MFSD5 MS4A13 NME2 NOX1 PRDX4 PRKCA PSMA7 PSME3 PTGIR RAB11A RACK1 RAF1 RPGRIP1L SLC35B4 SLC41A1 TM4SF4 VRK2 YWHAZ ZDHHC15	7 interacting genes: APPL1 CEP350 DPH3 NAA20 NFKBIL1 STK11 TBXA2R
Entrez ID		6915	51094
HPRD ID		01768	06402
Ensembl ID		ENSG00000006638	ENSG00000159346
Uniprot IDs		P21731 Q05C92 Q0VAB0	Q96A54
PDB IDs		1LBN	5LXG 6KRZ 6KS0
Enriched GO Terms of Interacting Partners?
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