SLPI and LAT

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLPI	LAT
Description		secretory leukocyte peptidase inhibitor	linker for activation of T cells
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Membrane Raft
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Negative Regulation Of Viral Genome Replication Innate Immune Response	Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity Regulation Of T Cell Activation
Pathways		Neutrophil degranulation	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2
Entrez ID		6590	27040
HPRD ID		00121	03832
Ensembl ID		ENSG00000124107	ENSG00000213658
Uniprot IDs		P03973	A0A024QZD6 O43561
PDB IDs		2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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