SLPI and CALN1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLPI	CALN1
Description		secretory leukocyte peptidase inhibitor	calneuron 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Plasma Membrane Integral Component Of Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding	Calcium Ion Binding Protein Binding
	Biological Process	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Negative Regulation Of Viral Genome Replication Innate Immune Response
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)	Age at first birth ( 34211149) Airflow obstruction ( 22837378) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Chronotype ( 30696823) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Corneal astigmatism ( 29422769) Emotional recognition ( 32366958) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Lifetime average cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Logical memory (delayed recall) in normal cognition ( 29274321) Refractive error ( 32231278) Schizophrenia ( 28991256 30285260) Sedentary behaviour duration ( 30531941) Triglyceride levels ( 32203549 32154731)
Interacting Genes		25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	9 interacting genes: DNAJC30 FATE1 LIME1 MAL PLP1 SEC22A SLPI SYCE1L USE1
Entrez ID		6590	83698
HPRD ID		00121	06209
Ensembl ID		ENSG00000124107	ENSG00000183166
Uniprot IDs		P03973	A4D1Z1 Q9BXU9
PDB IDs		2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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