LAT and OPRM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		LAT	OPRM1
Description		linker for activation of T cells	opioid receptor mu 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Membrane Raft	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Axon Dendrite Dendrite Membrane Dendrite Cytoplasm Sarcolemma Neuron Projection Perikaryon Membrane Raft Spine Apparatus Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Protein Binding Protein Kinase Binding Signaling Receptor Complex Adaptor Activity	G-protein Alpha-subunit Binding G Protein-coupled Receptor Activity Beta-endorphin Receptor Activity Voltage-gated Calcium Channel Activity Protein Binding Protein C-terminus Binding Protein Domain Specific Binding Filamin Binding G-protein Beta-subunit Binding Morphine Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity Regulation Of T Cell Activation	Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Negative Regulation Of Cell Population Proliferation Response To Radiation Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Food Positive Regulation Of Appetite Response To Lipopolysaccharide G Protein-coupled Opioid Receptor Signaling Pathway Wound Healing Response To Cocaine Eating Behavior Estrous Cycle Behavioral Response To Ethanol Positive Regulation Of Neurogenesis Regulation Of Sensory Perception Of Pain Excitatory Postsynaptic Potential Negative Regulation Of Wnt Protein Secretion Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Response To Growth Factor Cellular Response To Morphine Regulation Of Cellular Response To Stress Negative Regulation Of Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of NMDA Receptor Activity
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules	Opioid Signalling G-protein activation Peptide ligand-binding receptors G alpha (i) signalling events Interleukin-4 and Interleukin-13 signaling MECP2 regulates neuronal receptors and channels
Drugs			Tramadol Morphine Codeine Amitriptyline Hydromorphone Methadone Meperidine Oxycodone Levallorphan Dextromethorphan Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Alfentanil Fentanyl Loperamide Nalbuphine Levorphanol Remifentanil Ondansetron Anileridine Buprenorphine Hydrocodone Diphenoxylate Naloxone Oxymorphone Dezocine Ketamine Levacetylmethadol Aripiprazole Methadyl acetate 3-Methylthiofentanyl Dimethylthiambutene Diamorphine Ethylmorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Epicept NP-1 LI-301 Tapentadol Nalmefene Alvimopan Morphine glucuronide Ketobemidone Methylnaltrexone Naloxegol Cannabidiol Trimebutine Butyrfentanyl Pholcodine Eluxadoline Tianeptine Opium Pentoxyverine Naldemedine Metenkefalin Medical Cannabis Nabiximols Loxicodegol Oliceridine
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)	Adult body size ( 32376654) Body size at age 10 ( 32376654) Diastolic blood pressure ( 30224653) HDL cholesterol levels ( 32203549) Hypertension ( 21347282) Lipoprotein (a) levels ( 26377243) Menstruation quality of life impact (fever) ( 29855537) Methadone dose in opioid dependence ( 28115739) Nontraumatic osteonecrosis of the femoral head ( 32701715) Opioid use disorder ( 32492095) Type 2 diabetes (age of onset) ( 28060188)
Interacting Genes		95 interacting genes: APH1A ASGR2 BCL2L13 BSCL2 CAMLG CBL CD244 CD3G CD4 CD53 CD8A CDIP1 CLDN2 CLDN5 CLDN7 CREB3 CXorf66 CYBC1 EGFR FCGR1A FCGR2A FFAR2 FFAR3 FKBP7 FYN GAB2 GJA8 GJB1 GJB3 GOLM1 GPR101 GPR151 GPR152 GPR42 GRAP GRAP2 GRB2 ITK JSRP1 KASH5 KCTD17 KIR2DL3 LCK LCP2 LEUTX LHFPL1 LHFPL5 LMNA MAP1LC3C MAP4K1 MEOX2 MFF MFSD14B MFSD5 MRPS18B MS4A7 MTIF3 NDUFAF2 OPRM1 PIK3R1 PLCG1 PLCG2 PRR4 PSCA PTPN1 PTPN6 PTPRJ SAR1A SERINC2 SGTA SGTB SH3BP2 SHB SLA SLC14A2 SLC16A2 SLC18A1 SLC19A3 SLC26A6 SLC35C2 SLC51B SLPI SSMEM1 SYK SYT2 THAP4 TM4SF18 TMEM237 TMEM45B TMEM80 TNFRSF10D VAV1 ZAP70 ZDHHC7 ZHX2	78 interacting genes: ADAM33 ADD3 ALOX5AP ATP6V0C ATP6V0E1 C2CD2L CALM1 CCDC167 CD302 CLCN7 CLDN10 CLDN22 CLDN8 CLEC12B CLEC7A CNIH1 COPS5 CPLX1 CTXN3 CYB561 DNAJB4 DOK4 DOK5 DRD2 EHHADH EMP1 EMP3 FLNA GJA4 GNA15 GNAI1 GNAI2 GNAO1 GPRASP1 GRK3 GRM1 HS6ST1 IFITM3 KCNF1 LAT LPAR3 LRRC25 MAL MALL MAP1LC3A MAP1LC3C MFF NELFA NSG1 OPRD1 OPRL1 PLD2 PLD3 PMP22 PPL RPRM RTP4 SCGB1D1 SEC22A SERP2 SIAH1 SIAH2 SLC30A2 SLC38A7 SLC39A13 SLC41A1 SLC9A9 SMAGP TEX264 TM4SF4 TMBIM6 TMEM236 TRARG1 UBC VAPA WLS YIPF3 ZYX
Entrez ID		27040	4988
HPRD ID		03832	02484
Ensembl ID		ENSG00000213658	ENSG00000112038
Uniprot IDs		A0A024QZD6 O43561	B8K2Q5 G8XRH4 G8XRH5 L0E130 P35372
PDB IDs
Enriched GO Terms of Interacting Partners?
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