SLPI and CIB3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SLPI	CIB3
Description		secretory leukocyte peptidase inhibitor	calcium and integrin binding family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Specific Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	DNA Binding MRNA Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding	Magnesium Ion Binding Calcium Ion Binding Protein Binding
	Biological Process	Immune Response Negative Regulation Of Endopeptidase Activity Antibacterial Humoral Response Negative Regulation Of Protein Binding Response To Lipopolysaccharide Modulation Of Process Of Other Organism Negative Regulation Of Viral Genome Replication Innate Immune Response
Pathways		Neutrophil degranulation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576 28240269) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Malaria ( 31844061)	Lymphocyte counts ( 32888494)
Interacting Genes		25 interacting genes: CALN1 CIB3 CTSB CTSL CTSS EFEMP1 ELANE FAM9B GRN HOXA1 KLK3 LAT MAPK8IP2 MICOS10-NBL1 MKRN3 NBL1 NTAQ1 PIH1D2 PLSCR1 PRSS2 SGTA SGTB SMIM14 UBQLN1 UBQLN2	53 interacting genes: ARMC8 BEND7 C17orf50 ENOX2 GMCL1 KASH5 KLF17 LNX1 MEOX1 MEOX2 NANOS3 NME4 PAX5 PAX6 POLR2G POU6F2 RBAK REL SCNM1 SERTAD1 SLPI SP3 SP4 SYPL1 TACC3 TLE5 TRAF5 TRIM14 TRIM2 ZBTB43 ZC2HC1C ZFP1 ZFP57 ZNF146 ZNF177 ZNF180 ZNF19 ZNF276 ZNF317 ZNF329 ZNF398 ZNF426 ZNF552 ZNF559-ZNF177 ZNF578 ZNF597 ZNF620 ZNF664 ZNF688 ZNF774 ZNF835 ZSCAN4 ZSCAN5A
Entrez ID		6590	117286
HPRD ID		00121	16713
Ensembl ID		ENSG00000124107	ENSG00000141977
Uniprot IDs		P03973	Q96Q77
PDB IDs		2Z7F 4DOQ
Enriched GO Terms of Interacting Partners?
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