SELE and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 14568956)
24

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SELE	SERPING1
Description		selectin E	serpin family G member 1
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling	Negative Regulation Of Complement Activation, Lectin Pathway Complement Activation, Classical Pathway Aging Blood Coagulation Blood Circulation Negative Regulation Of Endopeptidase Activity Fibrinolysis Innate Immune Response
Pathways		Cell surface interactions at the vascular wall	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin	PPL-100 Copper
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		15 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 TRIM54 VCL	16 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		6401	710
HPRD ID		00566	06033
Ensembl ID		ENSG00000007908	ENSG00000149131
Uniprot IDs		P16581	E9KL26 P05155
PDB IDs		1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK	1M6Q 2OAY 5DU3 5DUQ
Enriched GO Terms of Interacting Partners?
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