SELE and PXN

Number of citations of the paper that reports this interaction (PubMedID 8609175)
32

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SELE	PXN
Description		selectin E	paxillin
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Stress Fiber Cytosol Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	Transcription Coregulator Activity Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling	Regulation Of Transcription, DNA-templated Cell Adhesion Cell-matrix Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway
Pathways		Cell surface interactions at the vascular wall	GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		15 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 TRIM54 VCL	90 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK IMPDH2 ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PCM1 PDPK1 PKD1 PLEKHH2 PLEKHN1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SCARB1 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN YES1
Entrez ID		6401	5829
HPRD ID		00566	03937
Ensembl ID		ENSG00000007908	ENSG00000089159
Uniprot IDs		P16581	A0A140VJQ8 P49023
PDB IDs		1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK	1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N
Enriched GO Terms of Interacting Partners?
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