SELE and SELL

Number of citations of the paper that reports this interaction (PubMedID 9024699)
41

Data Source:
HPRD (in vitro)

		SELE	SELL
Description		selectin E	selectin L
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit External Side Of Plasma Membrane Cortical Cytoskeleton Membrane Raft Perinuclear Region Of Cytoplasm	Plasma Membrane Integral Component Of Plasma Membrane Secretory Granule Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Sialic Acid Binding Phospholipase Binding Metal Ion Binding Oligosaccharide Binding	Protease Binding Calcium Ion Binding Protein Binding Heparin Binding Carbohydrate Binding Glycosphingolipid Binding Oligosaccharide Binding
	Biological Process	Positive Regulation Of Receptor Internalization Leukocyte Migration Involved In Inflammatory Response Inflammatory Response Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Activation Of Phospholipase C Activity Calcium-mediated Signaling Actin Filament-based Process Response To Lipopolysaccharide Response To Cytokine Response To Tumor Necrosis Factor Regulation Of Inflammatory Response Leukocyte Tethering Or Rolling Response To Interleukin-1 Positive Regulation Of Leukocyte Tethering Or Rolling	Cell Adhesion Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Tethering Or Rolling
Pathways		Cell surface interactions at the vascular wall	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Neutrophil degranulation
Drugs		Carvedilol N-acetyl-alpha-neuraminic acid Endostatin
Diseases
GWAS		Blood protein levels ( 30072576) Inflammatory bowel disease ( 26192919) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494)	Acne (severe) ( 24399259) Amyotrophic lateral sclerosis ( 19451621) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Monocyte count ( 32888494)
Interacting Genes		15 interacting genes: ACTA2 ACTN2 CD44 FLNA GLG1 LGALS3BP PLCG1 PTK2 PTPN11 PXN SELL SELPLG SERPING1 TRIM54 VCL	16 interacting genes: CD4 CFH EMCN EZR GRB2 MSN MUC7 PODXL PODXL2 PRKCA PRKCQ PRKG1 SELE SELPLG SLC30A2 VCAN
Entrez ID		6401	6402
HPRD ID		00566	07034
Ensembl ID		ENSG00000007908	ENSG00000188404
Uniprot IDs		P16581	P14151
PDB IDs		1ESL 1G1T 1KJA 4C16 4CSY 6EYI 6EYJ 6EYK	1KJB 2LGF 3CFW 5VC1
Enriched GO Terms of Interacting Partners?
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