PNPO and LIME1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PNPO	LIME1
Description		pyridoxamine 5'-phosphate oxidase	Lck interacting transmembrane adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Extracellular Space Integral Component Of Membrane B Cell Receptor Complex
	Molecular Function	Pyridoxamine-phosphate Oxidase Activity Protein Binding FMN Binding Pyridoxal Phosphate Binding Protein Homodimerization Activity	Protein Binding Protein Kinase Binding
	Biological Process	Pyridoxine Biosynthetic Process Pyridoxal Phosphate Biosynthetic Process	Adaptive Immune Response Regulation Of Transcription By RNA Polymerase II Regulation Of Phosphatidylinositol 3-kinase Signaling Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of MAP Kinase Activity T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of NIK/NF-kappaB Signaling
Pathways		Vitamins B6 activation to pyridoxal phosphate
Drugs		Pyridoxal phosphate Flavin mononucleotide Mercaptoethanol
Diseases
GWAS		Body mass index ( 26426971) Generalized epilepsy ( 30531953 22949513)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Apolipoprotein A1 levels ( 33730874) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Bell's palsy ( 33602968) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31015462) Inflammatory bowel disease ( 28067908 23128233) Meat-related diet ( 32066663) Prostate cancer ( 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908)
Interacting Genes		4 interacting genes: AGTRAP APP CMTM5 LIME1	46 interacting genes: AGR3 AIG1 AQP1 ARFGAP3 BNIP2 C14orf180 CALN1 CIAO2A CLN6 EMD FRMD8 GAD2 GOSR2 GRB2 LCK LHFPL5 LPAR3 LYN MAN2B2 MEST MIEF2 NDRG4 NINJ1 PBX3 PKMYT1 PLCG2 PNPO PTPN9 RTP2 SEC22C SLC41A2 SNAP47 SNX1 STX6 STX7 TBRG4 TMBIM6 TMEM143 TMEM243 TMEM74 TMEM86B TMEM97 TRAF3IP3 UNC93B1 UPK2 ZFPL1
Entrez ID		55163	54923
HPRD ID		04476	07904
Ensembl ID		ENSG00000108439	ENSG00000203896
Uniprot IDs		Q9NVS9 V9HW45	A0A087WT39 Q9H400
PDB IDs		1NRG 3HY8 6H00
Enriched GO Terms of Interacting Partners?
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