RNF216 and UBAC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RNF216	UBAC1
Description		ring finger protein 216	UBA domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Schaffer Collateral - CA1 Synapse Postsynaptic Endocytic Zone Glutamatergic Synapse	Golgi Apparatus Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Apoptotic Process Negative Regulation Of Type I Interferon Production Regulation Of Interferon-beta Production Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Defense Response To Virus By Host Protein K48-linked Ubiquitination Protein Catabolic Process, Modulating Synaptic Transmission	Protein Ubiquitination
Pathways		Negative regulators of DDX58/IFIH1 signaling	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Lung adenocarcinoma (survival time) in never smokers ( 32699080) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908)
Interacting Genes		30 interacting genes: AGFG1 BRCA1 CAPN15 FAM168A KIR2DL4 MAPK1 MORC3 OPTN RIPK1 RNF11 SUMO2 TLR3 TLR4 TLR5 TLR9 TNFAIP3 TRAF3 UBAC1 UBASH3A UBASH3B UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L3 UBE2L6 USP5 YOD1 ZFAND2A	36 interacting genes: AIRE APP ARRDC3 CARD14 CCDC138 CDKN1B CPSF6 CSNK2A1 DAZAP2 DVL2 FAM168A HOXA2 HTT IGFBP6 LAPTM5 MAP3K1 MCM10 MGAT3 NEDD4L PLAAT2 PLEKHB2 PMPCA POU6F2 PPP1CB RNF11 RNF123 RNF216 SMURF1 SPART TRIM2 TRIM39 UBB UBC UBQLN2 ZDHHC17 ZG16B
Entrez ID		54476	10422
HPRD ID		15550	12170
Ensembl ID		ENSG00000011275	ENSG00000130560
Uniprot IDs		A8K8N1 Q9NWF9	A0A140VK64 Q9BSL1
PDB IDs			2DAI
Enriched GO Terms of Interacting Partners?
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